[HTML][HTML] Oxidative stress and heart failure: mechanisms, signalling pathways, and therapeutics
… approached distinctive causes of heart failure in both humans … of novel targets for heart failure
prevention and therapy. In this … its therapeutic potential against cardiac oxidative damage. …
prevention and therapy. In this … its therapeutic potential against cardiac oxidative damage. …
Anemia as a risk factor and therapeutic target in heart failure
GM Felker, KF Adams, WA Gattis… - Journal of the American …, 2004 - jacc.org
… Anemia has recently been recognized as an important comorbid condition and potentially
novel therapeutic target in patients with heart failure (HF). Anemia is common in HF patients, …
novel therapeutic target in patients with heart failure (HF). Anemia is common in HF patients, …
Therapeutic applications of cannabinoids in cardiomyopathy and heart failure
JA Garza-Cervantes… - Oxidative Medicine …, 2020 - Wiley Online Library
… Many authors have studied the cardiovascular effects of CBD to explore its therapeutic
potential in a variety of cardiomyopathies, from healing injury caused by several cell stressors to …
potential in a variety of cardiomyopathies, from healing injury caused by several cell stressors to …
SGLT‐2 inhibitors in heart failure: current management, unmet needs, and therapeutic prospects
CSP Lam, C Chandramouli, V Ahooja… - … of the American Heart …, 2019 - Am Heart Assoc
… Outcomes of several ongoing prospective studies of SGLT‐2 inhibitors in HF (Figure 3) are
needed to fully evaluate the therapeutic potential of SGLT‐2 inhibitors in HF, with and without …
needed to fully evaluate the therapeutic potential of SGLT‐2 inhibitors in HF, with and without …
Gene therapy in heart failure
LE Vinge, PW Raake, WJ Koch - Circulation research, 2008 - Am Heart Assoc
… The therapeutic potential of SERCA2a gene transfer to failing myocardial tissue has also …
The therapeutic potential of SERCA2a gene delivery has also been recently addressed in a …
The therapeutic potential of SERCA2a gene delivery has also been recently addressed in a …
Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
RL Montgomery, TG Hullinger, HM Semus… - Circulation, 2011 - Am Heart Assoc
… To determine the therapeutic potential of miR-208a inhibition in cardiomyocytes in vivo, we
designed an LNA-containing anti-miR targeting bases 2 to 17 of the 5′ region of mature miR…
designed an LNA-containing anti-miR targeting bases 2 to 17 of the 5′ region of mature miR…
Reverse remodeling in heart failure—mechanisms and therapeutic opportunities
N Koitabashi, DA Kass - Nature Reviews Cardiology, 2012 - nature.com
… Despite great advances in the understanding and treatment of heart failure (HF), the disease
remains a leading cause of death worldwide. As patients with advanced HF outnumber …
remains a leading cause of death worldwide. As patients with advanced HF outnumber …
Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure
C Bergamini, M Cicoira, A Rossi… - … journal of heart failure, 2009 - Wiley Online Library
… Excess interstitial fibrosis is an important detrimental aspect of chronic LVH and chronic
heart failure (CHF). Oxidative stress is well known to be pro-fibrotic in many organs, and recent …
heart failure (CHF). Oxidative stress is well known to be pro-fibrotic in many organs, and recent …
Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity
DK Lee, SR George, BF O'Dowd - Trends in pharmacological sciences, 2006 - cell.com
The apelin receptor was initially classed as an orphan G-protein-coupled receptor, and little
was known about its physiological functions until apelin, the endogenous ligand, was …
was known about its physiological functions until apelin, the endogenous ligand, was …
Mitochondrial function as a therapeutic target in heart failure
DA Brown, JB Perry, ME Allen, HN Sabbah… - Nature Reviews …, 2017 - nature.com
… Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. … given that most patients with heart failure have viable dysfunctional …
worsening heart failure. … given that most patients with heart failure have viable dysfunctional …