MicroRNAs in heart failure: from biomarker to target for therapy

EL Vegter, P van der Meer, LJ de Windt… - … of heart failure, 2016 - Wiley Online Library
… A recent study by our group identified a panel of acute heart failure-specific miRNAs, in
which decreased miRNA levels were observed in acute heart failure patients compared with …

Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice

JW Calvert, M Elston, CK Nicholson, S Gundewar… - Circulation, 2010 - Am Heart Assoc
… present study evaluated the therapeutic potential of H 2 S in murine models of heart failure.
… Therefore, the purpose of the present study was to investigate the potential cardioprotective …

Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy

B Olshansky, HN Sabbah, PJ Hauptman, WS Colucci - Circulation, 2008 - Am Heart Assoc
Muscarinic receptors reside in both the atria and ventricles but have a greater density in the
former. 6 They occur more in the endocardium than in the epicardium. Muscarinic receptors …

… failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure …

C Maack, M Lehrke, J Backs, FR Heinzel… - European heart …, 2018 - academic.oup.com
… Systemic interdependence of heart failure and type 2 diabetes mellitus. In heart failure, …
/or infarction bias towards systolic dysfunction (heart failure with reduced ejection fraction), …

Developing therapies for heart failure with preserved ejection fraction: current state and future directions

J Butler, GC Fonarow, MR Zile, CS Lam, L Roessig… - JACC: Heart Failure, 2014 - jacc.org
The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is
projected to worsen. To date, there are no approved therapies available for reducing mortality …

Targeting Fibrosis for the Treatment of Heart Failure: A Role for Transforming Growth Factor‐β

AJ Edgley, H Krum, DJ Kelly - Cardiovascular therapeutics, 2012 - Wiley Online Library
… ECM) provide a potential therapeutic target for prevention of heart failure. This review focuses
on the therapeutic targeting of TGF‐β in the prevention of pathological fibrosis in the heart. …

Gene therapy for heart failure

L Tilemann, K Ishikawa, T Weber, RJ Hajjar - Circulation research, 2012 - Am Heart Assoc
… Today's science has yet to provide a cure, and there are few therapeuticheart failure.
There is a critical need to explore new therapeutic approaches in heart failure, and gene therapy

Cellular therapeutics for heart failure: focus on mesenchymal stem cells

AC Pandey, JJ Lancaster, DT Harris… - Stem Cells …, 2017 - Wiley Online Library
… The therapeutic potential of MSCs makes them the ideal … for “off the shelf use” potential in
cellular therapeutics; their … to be expanded to sufficient therapeutic quantities ex vivo [3, 7, …

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

YK Tham, BC Bernardo, JYY Ooi, KL Weeks… - Archives of …, 2015 - Springer
… from adaptive cardiac remodeling to maladaptive remodeling and heart failure. Treatment
strategies for heart failure commonly include diuretics, angiotensin converting enzyme …

Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

FI Malik, JJ Hartman, KA Elias, BP Morgan… - Science, 2011 - science.org
… , heart failure is marked by a decrease in cardiac contractility and called systolic heart failure
(3). … Current heart failure therapies rely on two different strategies. The most successful is to …