MicroRNAs in heart failure: from biomarker to target for therapy
EL Vegter, P van der Meer, LJ de Windt… - … of heart failure, 2016 - Wiley Online Library
… A recent study by our group identified a panel of acute heart failure-specific miRNAs, in
which decreased miRNA levels were observed in acute heart failure patients compared with …
which decreased miRNA levels were observed in acute heart failure patients compared with …
Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice
JW Calvert, M Elston, CK Nicholson, S Gundewar… - Circulation, 2010 - Am Heart Assoc
… present study evaluated the therapeutic potential of H 2 S in murine models of heart failure.
… Therefore, the purpose of the present study was to investigate the potential cardioprotective …
… Therefore, the purpose of the present study was to investigate the potential cardioprotective …
Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy
Muscarinic receptors reside in both the atria and ventricles but have a greater density in the
former. 6 They occur more in the endocardium than in the epicardium. Muscarinic receptors …
former. 6 They occur more in the endocardium than in the epicardium. Muscarinic receptors …
… failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure …
… Systemic interdependence of heart failure and type 2 diabetes mellitus. In heart failure, …
/or infarction bias towards systolic dysfunction (heart failure with reduced ejection fraction), …
/or infarction bias towards systolic dysfunction (heart failure with reduced ejection fraction), …
Developing therapies for heart failure with preserved ejection fraction: current state and future directions
The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is
projected to worsen. To date, there are no approved therapies available for reducing mortality …
projected to worsen. To date, there are no approved therapies available for reducing mortality …
Targeting Fibrosis for the Treatment of Heart Failure: A Role for Transforming Growth Factor‐β
AJ Edgley, H Krum, DJ Kelly - Cardiovascular therapeutics, 2012 - Wiley Online Library
… ECM) provide a potential therapeutic target for prevention of heart failure. This review focuses
on the therapeutic targeting of TGF‐β in the prevention of pathological fibrosis in the heart. …
on the therapeutic targeting of TGF‐β in the prevention of pathological fibrosis in the heart. …
Gene therapy for heart failure
L Tilemann, K Ishikawa, T Weber, RJ Hajjar - Circulation research, 2012 - Am Heart Assoc
… Today's science has yet to provide a cure, and there are few therapeutic … heart failure.
There is a critical need to explore new therapeutic approaches in heart failure, and gene therapy …
There is a critical need to explore new therapeutic approaches in heart failure, and gene therapy …
Cellular therapeutics for heart failure: focus on mesenchymal stem cells
AC Pandey, JJ Lancaster, DT Harris… - Stem Cells …, 2017 - Wiley Online Library
… The therapeutic potential of MSCs makes them the ideal … for “off the shelf use” potential in
cellular therapeutics; their … to be expanded to sufficient therapeutic quantities ex vivo [3, 7, …
cellular therapeutics; their … to be expanded to sufficient therapeutic quantities ex vivo [3, 7, …
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets
… from adaptive cardiac remodeling to maladaptive remodeling and heart failure. Treatment
strategies for heart failure commonly include diuretics, angiotensin converting enzyme …
strategies for heart failure commonly include diuretics, angiotensin converting enzyme …
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure
FI Malik, JJ Hartman, KA Elias, BP Morgan… - Science, 2011 - science.org
… , heart failure is marked by a decrease in cardiac contractility and called systolic heart failure
(3). … Current heart failure therapies rely on two different strategies. The most successful is to …
(3). … Current heart failure therapies rely on two different strategies. The most successful is to …