Pathophysiology and current therapy of congestive heart failure

WW Parmley - Journal of the American College of Cardiology, 1989 - Elsevier
… A traditional definition of congestive heart failure is “the inability of the heart to … heart failure
as we see it in clinical practice. The two major symptom complexes of congestive heart failure

… Na+/H+ Exchanger: A Potential Therapeutic Target for the Prevention of Myocardial Ischaemic and Reperfusion Injury and Attenuation of Postinfarction Heart Failure

M Karmazyn, JV Sostaric, XT Gan - Drugs, 2001 - Springer
… to the eventual development of heart failure. As such, a potential added benefit of NHE1
inhibitors may include attenuation of the evolution of infarcted myocardium to failure. The aim of …

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

K Sharma, DA Kass - Circulation research, 2014 - Am Heart Assoc
… Similar findings were reported by the New York Heart Failure Registry, with black HFpEF
patients also reporting worse renal function. These differences as recently reviewed by Shah …

The pharmacology of potassium channels and their therapeutic potential

NS Cook - Trends in Pharmacological Sciences, 1988 - Elsevier
heart failure and hypertension. In contrast, K + channels have until now gained little recognition
as a site for therapeutic … nels ix controlling the membrane potential (and hence excitability…

Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure

LB Arendse, AHJ Danser, M Poglitsch, RM Touyz… - Pharmacological …, 2019 - ASPET
… These advances have opened new avenues for the development of novel drugs targeting
the RAS to better treat hypertension and heart failure. Here we focus on new therapies in …

Treating oxidative stress in heart failure: past, present and future

A van der Pol, WH van Gilst, AA Voors… - … of Heart Failure, 2019 - Wiley Online Library
… the treatment of heart failure by targeting oxidative stress. Finally, we discuss the future potential
of … stress defence mechanisms, to improve clinical outcome in patients with heart failure. …

Long-term use of sildenafil in the therapeutic management of heart failure

M Guazzi, M Samaja, R Arena, M Vicenzi… - Journal of the American …, 2007 - jacc.org
… This study sought to test the functional exercise capacity and endothelial function in a
cohort of chronic heart failure (CHF) patients treated with chronic type 5 phosphodiesterase (PDE …

Exercise Intolerance in Chronic Heart Failure–Skeletal Muscle Dysfunction and Potential Therapies–

K Okita, S Kinugawa, H Tsutsui - Circulation Journal, 2013 - jstage.jst.go.jp
… xercise intolerance is a major clinical manifestation in patients with chronic heart failure (CHF).
It was originally considered to be the result of a failure of perfusion to the exercising …

[PDF][PDF] The role of inflammation in heart failure: new therapeutic approaches

E Oikonomou, D Tousoulis, G Siasos… - Hellenic J …, 2011 - cardiacos.net
… ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed
systolic heart failure (Hellenic Heart Failure Study). Heart Vessels. 2009; 24: 22-26. 39. …

[HTML][HTML] Pathophysiology of heart failure

RHG Schwinger - Cardiovascular diagnosis and therapy, 2021 - ncbi.nlm.nih.gov
… Genetic profiles may influence risk and prognosis as well as therapeutic options of heart
failure eg, defibrillator implantation in high risk mutations for hypertrophy. Heart failure patients …