… , new potential therapeutic targets that are involved in the pathogenesis of heart failure have
… This Review analyses the new therapeutic targets (for example, ventricular remodelling, …

… , or both that impair the ability of the heart to fill or eject blood. Common causes … heart
failure with depressed systolic function rather than the less-defined condition of heart failure …

… therapeutic targets as they are responsible for the direct or indirect control of most signalling
pathways in cells. Existing therapies for heart failure … in the progression of heart failure are …

… Heart failure is a major cause of cardiovascular morbidity … heart failure treatment guidelines,
emerging therapies that are undergoing clinical trial, and potential new therapeutic targets …

… in heart failure? Do other interventions known to improve endothelial function in heart failure
… would indeed represent an important therapeutic target in patients with chronic heart failure. …

… New therapeutic targets, agents, and strategies are needed to prevent and treat heart
failure (HF) after a decade of failed research efforts to improve long-term patient outcomes, …

… and chemokine targeting may hold therapeutic promise in heart failure, clinical translation …
of heart failure, and discusses the promises and challenges of targeted anti-cytokine therapy. …

… Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

… of heart failure are complex … failing heart to revive the myocardium and its contractile function.
This review highlights the 3 promising areas for the development of heart failure therapies, …

… remodeling and heart failure. Treatment strategies for heart failure commonly include …
that remain in translating these discoveries to new and approved therapies for heart failure. …