… Dilated cardiomyopathy and end-stage heart failure result in characteristic functional, …
protein, phospholamban, as potential therapeutic targets. We summarize structural and genetic …

… Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international
… been implicated in HF, making it a promising therapeutic target. APJ has been shown to be …

… as a potential therapeutic target. … or therapeutic effects in the energy-deprived failing heart.
In this chapter, we summarize the current knowledge on the energetic state of the failing heart, …

… of cardiovascular death or hospitalization for worsening of heart failure (A), on hospitalization
for worsening of heart failure (B), on death from heart failure (C), and on cardiovascular …

… therapy has emerged as an enigma for heart failure. Caspases promote the progressive loss
of contractile function in heart failure by … Therapeutic targets for heart failure: beyond beta-…

Heart failure (HF) with preserved ejection fraction (HFPEF) is an increasingly prevalent
clinical syndrome with many unresolved issues regarding diagnosis, pathophysiology, and …

… ACE2-Ang(1–7) axis with regards to clinical implications and therapeutic targets in cardiovascular
disorders, with emphasis on the potential therapeutic role in cardiovascular diseases. …

… -MR analyses of circulating protein levels for therapeutic target identification and prioritization
in HF, … the druggability properties of these proteins as potential therapeutic targets for HF. …

… disturbances that presage heart failure due to common … therapeutic target for novel
therapeutics aimed at reversing the energy metabolic disturbances that contribute to heart failure. …

… Heart rate not only predicts outcome but may also be a therapeutic target in patients with
chronic heart failure… Several classes of pharmacological agents can be used to modulate heart …