Disrupted serotonergic and sympathoadrenal systems in patients with chronic heart failure may serve as new therapeutic targets and novel biomarkers to assess …

RR Nigmatullina, VV Kirillova, RK Jourjikiya… - Cardiology, 2009 - karger.com
… of heart failure progression has recently become universally recognized. According to this
tenet, heart failure … diagnostic approaches and at the same time serve as therapeutic targets. …

Endoplasmic reticulum stress as a novel therapeutic target in heart diseases

A Toth, P Nickson, A Mandl… - … -Drug Targets  …, 2007 - ingentaconnect.com
… Puma, therefore, represents a potential therapeutic target to attenuate cell death in a variety
of different conditions, including ischemic heart disease, heart failure or during cell therapy

Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy

H Ashrafian, WJ McKenna, H Watkins - Circulation research, 2011 - Am Heart Assoc
Therapeutic targets in HCM are likely to be most effective when directed to the molecular …
heart failure and hypertrophic cardiomyopathy and for its use in systolic heart failure in …

miRNAs as therapeutic targets in ischemic heart disease

RJA Frost, E van Rooij - Journal of cardiovascular translational research, 2010 - Springer
… Ischemic heart disease is a form of congestive heart failure that is caused by insufficient …
therapeutic target for cardiac remodeling is miR-208. miR-208 is solely expressed in the heart as …

Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target

FG Spinale, ML Coker, BR Bond… - Cardiovascular …, 2000 - academic.oup.com
… Regulation of myocardial MMP expression and activity may be an important therapeutic
target for controlling myocardial matrix remodeling in the setting of developing heart failure. …

Signaling cascades in the failing heart and emerging therapeutic strategies

X He, T Du, T Long, X Liao, Y Dong… - … and targeted therapy, 2022 - nature.com
heart failure is the end stage of cardiac diseases. With a high prevalence and a high mortality
rate worldwide, chronic heart failure … novel insights for future therapeutic targets. On the …

Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart

W Liu, M Zi, R Naumann, S Ulm, J Jin, DM Taglieri… - Circulation, 2011 - Am Heart Assoc
… to heart failure, we extended the TAC stress imposed on Pak1 f/f and Pak1 cko mice to 5
weeks. Indeed, Pak1 cko mice showed characteristics of heart failure … confirmed heart failure, …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
therapeutic targets for several cardiovascular disorders. In this review we provides an overview
of the effects of several CVD; including heart failure, … miRNA as therapeutic targets is also …

MicroRNAs in heart failure: from biomarker to target for therapy

EL Vegter, P van der Meer, LJ de Windt… - … of heart failure, 2016 - Wiley Online Library
… to therapy. Several miRNAs have been related to important mechanisms leading to heart
failure… An increasing number of miRNAs and miRNA targets have been reported in heart failure

Heart rate variability–a therapeutic target?

HC Routledge, S Chowdhary… - … and therapeutics, 2002 - Wiley Online Library
… with moderate or severe heart failure, those with depressed … of death due to progressive heart
failure than conventional clinical … to high risk patients with heart failure or MI. Low HRV has …