… It is now well known that congestive heart failure (CHF) is … of cardiac hypertrophy to heart
failure are poorly understood. … , and enzyme activities in the failing heart become evident as a …

… Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure… most patients with heart failure have viable dysfunctional myocardium, …

… as immunosuppressants but are unsuitable for use in chronic heart failure because of their
side-effects. However, agents targeting other components of this pathway (eg, regulators of …

… in the failing heart remain viable, although metabolically … targeting the underlying molecular
defects in HF. In this review, we discuss the changes that occur in the mitochondria of failing …

… a viable therapeutic target. Several observational studies have pointed out the high prevalence
of significant mitral regurgitation in chronic systolic heart failure … in heart failure has been …

… have been developed to detect viable myocardium in patients with ischemic heart failure.
The different imaging techniques target different characteristics of viable myocardium (Table 2) …

… There are over one million hospitalizations for heart failure (HF) annually in the United
States alone [1], and a similar number has been reported in Europe. Despite all available …

… with and without scar tissue in the target region in QRS duration, the frequency of left bundle
branch block, LV dyssynchrony, the number of viable segments, and total scar score (Table …

… and controversies for viability imaging to direct … heart failure of ischemic origin (IHF). Different
stages of ischemia induce adaptive changes in myocardial metabolism and function. Viable …

… the relative risk of developing heart failure is modest, the … In this regard, this risk marker
serves as a most viable target … for developing heart failure and who should be targeted for …