Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven
disease due to the predominance of CD4 + T lymphocytes and their products in target organs …

… and IL-21-producing T follicular helper cells. In blood from pSS patients, frequently
observed … Proposed role of CD4+ T cells in primary Sjögren's syndrome (pSS) pathogenesis …

… - cells, called T peripheral helper cells, was described in the synovium and blood of patients
with RA and was found to be able to stimulate B cell activation 102 . These cells have also …

… B cell activation, as evidenced by the presence of anti-SSA (Sjögren syndrome A antigen),
anti-SSB (Sjögren syndrome … shown an expansion of plasma cells in minor salivary gland and …

… -helper (Th1, Th2 and Th17) cell activity in the peripheral blood of patients with primary
Sjögren's syndrome (pSS), non-Sjögren's sicca syndrome … blood mononuclear cells from 34 pSS, …

… of these are CD4 T helper (Th) cells [2], which, we note, are classified as Th1 and Th2 cells,
based on … blood CD25 high cells seems to be preserved in primary Sjögren’s syndrome [19]. …

… + cells in T helper-17 (Th17) cell-mediated corneal epithelial barrier disruption that develops
in a murine desiccating stress (DS) model that resembles Sjögren syndrome. CD8 + cell …

The aim of this study was to investigate the possible role of follicular helper T (T FH ) cells in
the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent …

… Sixteen primary Sjögren's syndrome patients and 16 controls where enrolled in this study, …
(AECG) criteria.13 for Primary Sjögren's syndrome (Table 1). Demographics and clinical data …

… Autoantigens can be released from SGECs and presented to immune cells. CD4 + T cells
differentiate into follicular helper T (T FH ) cells, which increase B cell survival. Interaction …