CRISPR‐Cas9 technology and its application in haematological disorders
H Zhang, N McCarty - British journal of haematology, 2016 - Wiley Online Library
… The CRISPR-Cas9 system is also a useful tool for delineating molecular mechanisms
involving haematological malignancies. Prior to the use of CRISPR-Cas9-mediated gene …
involving haematological malignancies. Prior to the use of CRISPR-Cas9-mediated gene …
CRISPR/Cas9 system: A promising technology for the treatment of inherited and neoplastic hematological diseases
JS Antony, AKMA Haque… - Advances in Cell …, 2018 - Wiley Online Library
… utilization of the CRISPR/Cas9 system as a possible treatment option for hemoglobinopathies
and hematological tumors. We summarize the recent advances with CRISPR/Cas9 and its …
and hematological tumors. We summarize the recent advances with CRISPR/Cas9 and its …
[HTML][HTML] Utility of CRISPR/Cas9 systems in hematology research
D Lucas, HA O'Leary, BL Ebert, CA Cowan… - … Hematology, 2017 - Elsevier
… applications of the CRISPR/Cas9 system, such as development of cell-based, clinically
relevant drug screens for complex hematological malignancies. The CRISPR/Cas9 system has …
relevant drug screens for complex hematological malignancies. The CRISPR/Cas9 system has …
Applying CRISPR-Cas9 screens to dissect hematological malignancies
DN Iyer, AD Schimmer, H Chang - Blood Advances, 2023 - ashpublications.org
… From a functional point of view, within hematological malignancies we have identified only
a small percentage of vulnerabilities using the current scale of CRISPR screening approaches…
a small percentage of vulnerabilities using the current scale of CRISPR screening approaches…
CRISPR/Cas9-mediated gene editing. A promising strategy in hematological disorders
L Ugalde, S Fañanas, R Torres… - Cytotherapy, 2023 - Elsevier
… Patients also show a high predisposition to hematological malignancies, such as acute …
editing in human primary hematopoietic cells using CRISPR/Cas9 technology. This disease is …
editing in human primary hematopoietic cells using CRISPR/Cas9 technology. This disease is …
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
D Heckl, MS Kowalczyk, D Yudovich, R Belizaire… - Nature …, 2014 - nature.com
… of current approaches for engineering murine malignancies and will allow rapid generation
of disease models beyond hematopoietic malignancies. Such models are critical for the …
of disease models beyond hematopoietic malignancies. Such models are critical for the …
CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia
AM Alayoubi, ZY Khawaji, MA Mohammed… - … of Hematology, 2024 - Springer
… The use of CRISPR-Cas9 genetic engineering in hematological disorders has been well-…
The employment of CRISPR-Cas9 in hematological malignancies is still in its early stages with …
The employment of CRISPR-Cas9 in hematological malignancies is still in its early stages with …
Therapeutic gene editing in haematological disorders with CRISPR/Cas9
TI Jensen, E Axelgaard, RO Bak - … journal of haematology, 2019 - Wiley Online Library
… methodology and applications in haematology for curing … treat haematological malignancies.
Furthermore, we discuss current challenges for full clinical implementation of CRISPR/Cas9…
Furthermore, we discuss current challenges for full clinical implementation of CRISPR/Cas9…
Multiplex CRISPR/Cas9-based genome editing in human hematopoietic stem cells models clonal hematopoiesis and myeloid neoplasia
… Hematologic malignancies are driven by combinations of genetic lesions … CRISPR/Cas9
genome engineering of primary adult and umbilical cord blood CD34 + human hematopoietic …
genome engineering of primary adult and umbilical cord blood CD34 + human hematopoietic …
CRISPR/Cas9-modified hematopoietic stem cells—present and future perspectives for stem cell transplantation
A Daniel-Moreno, A Lamsfus-Calle, J Raju… - Bone Marrow …, 2019 - nature.com
… hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for
hematological malignancies … However, the CRISPR/Cas9-edited autologous HSCs have been …
hematological malignancies … However, the CRISPR/Cas9-edited autologous HSCs have been …
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