… The CRISPR-Cas9 system is also a useful tool for delineating molecular mechanisms
involving haematological malignancies. Prior to the use of CRISPR-Cas9-mediated gene …

… utilization of the CRISPR/Cas9 system as a possible treatment option for hemoglobinopathies
and hematological tumors. We summarize the recent advances with CRISPR/Cas9 and its …

… applications of the CRISPR/Cas9 system, such as development of cell-based, clinically
relevant drug screens for complex hematological malignancies. The CRISPR/Cas9 system has …

… From a functional point of view, within hematological malignancies we have identified only
a small percentage of vulnerabilities using the current scale of CRISPR screening approaches…

… Patients also show a high predisposition to hematological malignancies, such as acute …
editing in human primary hematopoietic cells using CRISPR/Cas9 technology. This disease is …

… of current approaches for engineering murine malignancies and will allow rapid generation
of disease models beyond hematopoietic malignancies. Such models are critical for the …

… The use of CRISPR-Cas9 genetic engineering in hematological disorders has been well-…
The employment of CRISPR-Cas9 in hematological malignancies is still in its early stages with …

… methodology and applications in haematology for curing … treat haematological malignancies.
Furthermore, we discuss current challenges for full clinical implementation of CRISPR/Cas9…

… Hematologic malignancies are driven by combinations of genetic lesions … CRISPR/Cas9
genome engineering of primary adult and umbilical cord blood CD34 + human hematopoietic …

… hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for
hematological malignancies … However, the CRISPR/Cas9-edited autologous HSCs have been …