… Arterial vessels express one or more heme oxygenase (HO) isoenzymes that catalyze the
metabolism of heme to carbon monoxide (CO) and biliverdin. Carbon monoxide promotes …

… While regulation of heme biosynthesis is … of heme is controlled by microsomal heme
oxygenase (HO; EC 1.14.99.3) isoenzymes which catalyze the initial and rate limiting step in heme …

… Carbon monoxide (CO), a gaseous second messenger, arises in biological systems
during the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …

… Heme oxygenase (HO) degrades protoheme IX by cleaving its -methene bridge into carbon
monoxide (CO), free divalent iron (Fe2), and biliverdin-IX.The reaction uses nicotinamide …

… Tenhunen and Schmid in 1968: the catalytic breakdown of heme by the microsomal heme
oxygenase (HO) enzyme system which releases carbon monoxide (CO) (672, 674). Although …

… heme oxygenase (HO) activity in animal tissue preparations through determination of carbon
monoxide … to -78’C and the amount of carbon monoxide released into the headspace was …

… of the ubiquitous nature of heme oxygenase-1 (HO-… Heme oxygenase activity serves an
essential metabolic function as the rate-determining step in heme degradation, by cleaving heme…

… Role of heme oxygenase and carbon monoxide in lung diseases. Heme oxygenase (HO) …
(CO) arises principally as a product of heme metabolism, from the action of heme oxygenase …

… Heme oxygenases and carbon monoxide Heme oxygenases (HOs) catabolize heme into
three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin), and …

… 1, mediate their proangiogenic effects through induction of heme oxygenase-1, making it an
… role of heme oxygenase-1 and carbon monoxide in angiogenesis. Carbon monoxide (CO) is …