… The distal side of the heme oxygenase … activation of FeOOH species to promote the unique
self-oxidation (middle) and can be a potent target for specific inhibitors of heme oxygenase (…

… The activation of dioxygen by heme oxygenase proceeds via … is the case in the activation
of dioxygen by monooxygenase … and dynamic properties in heme oxygenase that channel the …

… of oxygen activation in heme oxygenase is expected to be different from these other
enzymes. Indeed, based on the generation of hydrogen peroxide by the heme-heme oxygenase …

… is the prototype of a dioxygen activating heme enzyme. The … , which facilitates the dioxygen
activation process at the iron … equivalents, and together with dioxygen give an Fe IV (O) π-…

… This ‘high-tech’ approach to activation of the oxygen in heme oxygenase provides a solid
link between the observations from peroxide reactions and the normal oxygen-dependent …

… heme … activate oxygen during the heme oxygenase reaction. In the conversion of hemin to
α-meso-hydroxyhemin, the active species of oxygen is Fe-OOH, which self-hydroxylates heme …

… activate the iron-bound dioxygen and hydroperoxide. On the basis of the present findings, we
propose an oxygen activation … 13 we propose an oxygen activation mechanism by HO and …

… heme degradation by the heme oxygenase system remains, for the most part, speculative.
The current belief is that heme oxygenase … caused in part by oxygen activation. Abraham et al. …

… Oxygen is activated by enzymes in a tightly controlled … is that intermediates in the oxygen
activation reaction are often short … interested in biological oxygen activation strategies in that the …

… Asp is not involved in the oxygen activation but stabilizes the water network to place
catalytically critical Wat1 at a position suitable for efficient Fe−OOH activation. (34) The different …