… HO‐1 is the commonly known heme oxygenase, the activity of which can be induced by up
to … findings on heme oxygenase are highlighted.— Maines, MD Heme oxygenase: function, …

… The heme oxygenases (HOs) play critical roles in physiological iron homeostasis,
antioxidant defense, and, as shown from the accumulating evidence, in signaling pathways that …

… was provided by 18O-labeling studies showing that the biosynthesis of phycocyanobilin
occurred via a two-molecule mechanism (141, 142) comparable to that of the mammalian …

… , heme oxygenase has evolved a similar structural and mechanistic scaffold to function within
seemingly diverse physiological pathways. The heme oxygenase … of heme oxygenase in …

… function of endothelial precursor cells (EPCs) through a mechanism dependent on HO-1
expression. Although the molecular mechanisms underlying the induction of VEGF and SDF-1 …

… Structural information is important to understand molecular mechanisms. It is easier to
understand how something works if one knows what it looks like, and it is true also for molecules …

… The functions of heme oxygenase. Heme oxygenase degrades heme into equimolar amounts
of iron, carbon monoxide (CO), and biliverdin (which, in most mammals, is subsequently …

… ] have similar active site structures and share a similar mechanism of heme degradation.
Thus, we consider that the mechanism of heme breakdown obtained from the studies on HO-1 …

… In this review, we provide a comprehensive overview on the molecular mechanisms
underlying the regulation and function of HO-1 and its clinical implications. In addition, the …

… We discuss the molecular mechanisms mediating the cytoprotective effects of HO-1 and how
these might be used therapeutically to overcome some of the major causes of morbidity and …