… The active site of heme oxygenase complexed with heme and azide (PDB ID 1IVJ). The azide
… 2 The active site of heme oxygenase complexed with heme and azide (PDB ID 1IVJ). The …

… Heme toxicity can be prevented by heme oxygenases (HOs), enzymes that are able to
catabolize heme, retrieving iron and producing biliverdin and carbon monoxide (CO) with the aid …

… The past decade or so has witnessed tremendous advances in our understanding of the
cellular and molecular mechanisms mediating cell death and survival in the mammalian …

… Understanding the cellular effects and molecular mechanisms of HO-1 gene expression
in response to TGF- will be important in designing interventional strategies in TGF- –mediated …

… Schmid and coworkers 1 were the first to report on the presence of heme oxygenase (HO)
in liver microsomes capable of degrading heme to bilirubin, and this activity was subsequently …

… Further studies are necessary to fully describe the role of HO-1 in disturbed cell differentiation
in other tumor types and to understand the molecular mechanism of the observed effects. …

… However, the exact molecular mechanisms by which it does so remain unknown. It is highly
recognized that HO-1 protein does not have a DNA-binding consensus sequence [10]. One …

… These results demonstrate that HO-1 activity operates through distinct molecular
mechanisms to confer cytoprotection in the hypoxic and the LPS models of inflammation. …

The heme oxygenase-1 (HO-1) system, the rate-limiting step in the conversion of heme, is
among the most critical of cytoprotective mechanisms activated during cellular stress. The …

… In this respect, recent studies have identified heme oxygenase-1 (HO-1) … mechanisms by
which HO-1 protects against atherosclerosis, focusing on cellular and molecular mechanisms …