… In this review, we summarize the essential roles that the HO system plays in ensuring
brain health and the molecular mechanism through which HO-1 dysfunction leads to …

… In this respect, recent studies have identified heme oxygenase-1 (HO-1) … mechanisms by
which HO-1 protects against atherosclerosis, focusing on cellular and molecular mechanisms …

… Recent Advances: The heme oxygenases (HO) are metabolic enzymes that utilize NADPH
and oxygen to break apart the heme moiety liberating biliverdin (BV), carbon monoxide (CO), …

… Heme oxygenase (HO) is the first and the rate limiting enzyme in the catabolism of heme (…
could represent a key molecular mechanism by which CO protects against hepatic I/R insult. …

… Abstract: Heme oxygenase-1 (HO-1), an enzyme degrading heme to … heme oxygenase
activity, but drugs activating the transcription actor Nrf2, which have a very diverse molecular …

… The latter is in agreement with the reported absence of heme oxygenase activity of this mutant
at room temperature. In contrast, the hydroperoxoferri-HO (D140A) intermediate denoted R…

… These results demonstrate that HO-1 activity operates through distinct molecular
mechanisms to confer cytoprotection in the hypoxic and the LPS models of inflammation. …

… However, to elucidate the molecular mechanism of HMOX1 activity would help to
understand those effects and to the development of new potential therapies for IBD (Figure 1B). …

… The past decade or so has witnessed tremendous advances in our understanding of the
cellular and molecular mechanisms mediating cell death and survival in the mammalian …

… The active site of heme oxygenase complexed with heme and azide (PDB ID 1IVJ). The azide
… 2 The active site of heme oxygenase complexed with heme and azide (PDB ID 1IVJ). The …