Heme oxygenase as a therapeutic target in immunological pregnancy complications

AC Zenclussen, A Sollwedel, AZ Bertoja… - International …, 2005 - Elsevier
… , iNOS and eNOS in mouse placental tissue by using IHC… pregnancy in the rat, which nicely
correlates with our findings on weak iNOS and eNOS staining on day 14 of mouse pregnancy

Regulation of maternal and fetal hemodynamics by heme oxygenase in mice

H Zhao, RJ Wong, TC Doyle, N Nayak… - Biology of …, 2008 - academic.oup.com
… ), a vasodilator derived from the heme degradation pathway. During pregnancy, the maternal
… maternal and fetal hemodynamics during pregnancy in a mouse model. We measured and …

Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy

ML Zenclussen, N Linzke, A Schumacher… - Frontiers in …, 2015 - frontiersin.org
… importance of the enzyme heme oxygenase-1 (HO-1) for pregnancy to be established and
… the success of pregnancy. The deletion of the gene Hmox1 in mice leads to inadequate …

Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells

A Schumacher, PO Wafula, A Teles, T El-Mousleh… - 2012 - journals.plos.org
… Successful human and murine pregnancies are clearly … in mice and is associated with
miscarriage in humans [13]–[17]. Treg treatment using cells exclusively from normal pregnant mice …

Heme oxygenase protects against placental vascular inflammation and abortion by the alarmin heme in mice

CM Suttorp, REM van Rheden, NWM van Dijk… - International journal of …, 2020 - mdpi.com
… To test this hypothesis, we administered heme to pregnant CD1 outbred mice at Day E12
by intraperitoneal injection in increasing doses: 30, 75 or 150 μmol/kg body weight (30H, 75H …

Heme oxygenase-1 in placental development and pathology

K Levytska, J Kingdom, D Baczyk, S Drewlo - Placenta, 2013 - Elsevier
… Furthermore, induction of abortion in mice with IL-12, a cytokine which upregulates the …
to proper placental development and pregnancy maintenance in mice via its anti-apoptotic …

The heme oxygenases: important regulators of pregnancy and preeclampsia

EM George, JP Warrington… - American Journal …, 2014 - journals.physiology.org
… of pregnancy. Early preclinical and clinical studies have associated defects in the heme
oxygenase … This review will summarize the role of heme oxygenases in pregnancy and highlight …

Heme oxygenase and the immune system in normal and pathological pregnancies

M Ozen, H Zhao, DB Lewis, RJ Wong… - Frontiers in …, 2015 - frontiersin.org
… In murine pregnancies, day E10.5 corresponds to the end of the first trimester in the human
pregnancy, and is an important gestational age (GA) when spiral artery remodeling occurs …

Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance

A Schumacher, AC Zenclussen - Frontiers in pharmacology, 2015 - frontiersin.org
… diseases and infections in pregnancy via modulation of … of pregnancy and this is thought
to be due to pregnancy-specific alterations of immune responses. In a well-established mouse

Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion

ML Zenclussen, I Anegon, AZ Bertoja… - Journal of reproductive …, 2006 - Elsevier
pregnancy would avoid fetal rejection in the murine abortion combination CBA/J × DBA/2J,
using BALB/c-mated CBA/J as normal controls. We injected pregnant … the pregnancy outcome …