… bound to the multiple Maf recognition elements (MAREs) of ho‐1 enhancers with MafK in
vitro and repressed their activity in vivo, while heme abrogated this repressor function of Bach1 …

… induction of Bach1, a heme-regulated transcriptional repressor, in human cells. Bach1 is a
… chelator desferrioxamine, each of which induced Bach1 expression. In contrast, induction of …

… In contrast, the transcriptional repressor BACH1 binds ARE-like enhancers in cells naïve
to … the dynamic roles of BACH1 and NRF2 in the transcription of the heme oxygenase-1 ( …

… 1 (Bach1) proteins in primary monocytes and leukemic cells. (A) Expression levels of HO-1,
Nrf2, and Bach1 … analyzed the transactivator Nrf2 and the repressor Bach1, both of which are …

… heme, inactivate the repressor Bach1 in distinct ways to achieve conditional gene expression
and suggest that the interpretation of various stimuli by Bach1 is critical in ho-1 regulation. …

… HO-1 expression is mainly governed by a mutual interplay between the transcriptional
factor NRF2 and the nuclear repressor BTB and CNC homology 1 (BACH1), a heme sensor …

… transcriptional repressor protein BACH1 [… repressor protein BACH1, and the binding of
BACH1 to the ARE is dominant over that of transactivating protein Nrf2 [11]. The effects of BACH1 …

… As HO-1 expression is mainly regulated at the transcription level (20), we examined the HO-1
transcriptional repressor Bach1 to determine the effect of RANKL-mediated HO-1 reduction …

… BACH1 inactivation on the induction of HMOX1 and as a mechanism for broader gene induction.
We show that BACH1 … Two heme oxygenase isoforms participate in heme metabolism: …

… repressor Bach1 plays a critical role in constraining the expression of oxidative stress
response genes [1]. For example, Bach1 represses the expression of heme oxygenase-1 (HO-1), …