The heme oxygenase system: update 2005

MD Maines - Antioxidants & redox signaling, 2005 - liebertpub.com
… of heme oxygenase (HO). Since then, the phenomenal rate of expansion of the field, which
extends its reach into the very core of many systems, … of the hemeheme oxygenase system in …

The heme oxygenase system and its functions in the brain.

MD Maines - Cellular and Molecular Biology (Noisy-le-Grand …, 2000 - europepmc.org
… The heme oxygenase (HO) system was identified in the early 1970s as a distinct microsomal
enzyme system that catalyzes formation of bile pigments (Maines and Kappas, 1974). Up to …

The heme oxygenase system: a regulator of second messenger gases

MD Maines - Annual review of pharmacology and toxicology, 1997 - annualreviews.org
▪ Abstract The heme oxygenase (HO) system consists of two forms identified to date: the
oxidative stress–inducible protein HO-1 (HSP32) and the constitutive isozyme HO-2. These …

Different faces of the heme-heme oxygenase system in inflammation

FA Wagener, HD Volk, D Willis, NG Abraham… - Pharmacological …, 2003 - ASPET
… the significance of heme and heme oxygenase is presented in view of biological and
pathological processes, with special reference to inflammation. In addition, the heme-HO system is …

The heme oxygenase system: past, present, and future

MD Maines - Antioxidants & redox signaling, 2004 - liebertpub.com
… Deliberating a physiological basis for the high-level expression of HO-2 in the brain led to
the proposal that “heme oxygenase in the brain has functions other than heme degradation”(54…

Heme oxygenase and the cardiovascular–renal system

NG Abraham, A Kappas - Free Radical Biology and Medicine, 2005 - Elsevier
… The hemeheme oxygenase (HO) system is a regulator of endothelial cell (EC) 1 integrity
and oxidative stress. Heme is the prosthetic group of numerous enzymes and is important to …

The heme oxygenase system: its role in liver inflammation

C Wunder, RF Potter - Current Drug Targets-Cardiovascular & …, 2003 - ingentaconnect.com
… regarding the cytoprotective properties provided by the activity of heme oxygenase (HO), the
rate-limiting enzyme in the degradation of heme. Although particular attention will be paid to …

The heme-heme oxygenase system: a molecular switch in wound healing

FA Wagener, HE van Beurden, JW von den Hoff… - Blood, 2003 - ashpublications.org
heme proteins and heme. Here, we investigated the involvement of heme and its degrading
enzyme heme oxygenase (… We observed that heme directly accumulates at the edges of the …

Heme oxygenase structure and mechanism

PRO de Montellano, A Wilks - 2000 - Elsevier
… The distinct steps in the oxidation of heme to biliverdin catalyzed by heme oxygenase. The
substituted carbons of the porphyrin ring are labeled, as are the mesopositions. The oxygens …

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

MD Maines - The FASEB journal, 1988 - Wiley Online Library
… known heme oxygenase, the activity of which can be induced … In this review recent findings
on heme oxygenase … MAINES, MD Heme oxygenase: function, multiplicity, regulatory …