… -S concentration: An important factor in the low oxygen affinity of blood in sickle cell anemia.
… of the heterogeneous distribution of hemoglobin types in sickle-cell anemia. J Clin Invest 47:…

… of sickle cell anemia (29, 36, 86). It is clear that intracellular hemoglobin polymerization is
the … Such polymerization begins at very high oxygen saturation, especially for the most dense …

… for non-S hemoglobin composition, for a cohort of 46 homozygous sickle cell anemia patients,
to quantitate all five cellular variables that modulate the intracellular polymer content of SS …

… The amount of polymer formed in thesubpopulations was … hemoglobin S gelation. We further
demonstrate that the erythrocyte density profile for a single individual with sickle cell anemia …

… The discovery by Pauling and his associates of the abnormal hemoglobin molecule,
hemoglobin S, 6 in sickle cell anemia, later identified by Ingram 7 as β 6Glu→Val , initiated several …

… event of sickle cell anemia is the polymerization of the mutant hemoglobin (Hb) S within the
red blood cells, occurring when … Polymerization is known to start with nucleation of individual …

… ABSTRACT In search of novel control parameters for the polymerization of sickle cell
hemoglobin (HbS), the primary pathogenic event of sickle cell anemia, we explore the role of free …

… following hemoglobin (Hb) S polymerization in sickle cell anemia (SS) red cells with …
that dehydrated SS red cells may sustain large polymerization-induced volume shifts whose …

… hemoglobin molecule will continue to extravasate. We have focused on developing a polymerized
form of hemoglobin … of this polymerized pyridoxylated hemoglobin solution (Poly SFH-…

… : homogeneous nucleation in solutions with hemoglobin activity above a critical activity, and
… contain hemoglobin polymers. The latter pathway is dominant, and creates polymer arrays …