… model or noncompartment approach is used (7, 8). … frequency response method in modeling
pharmacokinetic systems describing the fate of F VIII administered to hemophilia A patients …

… of 56 boys with severe hemophilia A to tailored, frequency-escalated prophylaxis with an …
than the general hemophilia population. For the CHPS, we excluded patients and families …

… basic characteristics of the ABR endpoint. In addition, we analyzed study protocols from
contemporary hemophilia … to characterize differences in the methodology of ABR estimation. The …

… with hemophilia A to have undergone an orthopedic procedure… higher among hemophilia
A than hemophilia B patients, and … to prevent all joint bleeding in US males with hemophilia. …

… Three of the six attributes accounted for >88% of the total impact of the elements included
in the study on the treatment decision process in hemophilia A ( Figure 2 ). Frequency of …

… It is suggested that the application of this methodology should increase our understanding
of the clinical significance of factors levels that could not be measured previously and thus …

… In addition, utilization of a PopPK method to derive individual PK … with hemophilia. To
facilitate understanding this potential we will compare and contrast it to the traditional approach. …

… Background: Prophylaxis with factor (F)VIII is considered the optimal treatment for
managing hemophilia A patients without inhibitors. Objectives: To compare the efficacy of two …

… patients with moderately severe to severe hemophilia A and summarize advances in tailoring
therapy to patient-… -PFM leading toward personalized care for patients with hemophilia A. …

… The use of EHL FVIII products in boys with severe hemophilia A will be an evolving process
… A pragmatic approach will be necessary to manage both clinician and patient expectations, …