A microcomputer program for individualizing factor VIII dosage in hemophilia patients undergoing major surgery

S Ruffo, A Messori, G Longo, M Matucci… - … Methods and Programs …, 1986 - Elsevier
microcomputer program can be of value to prospectively individualize the dosage of Factor
VIII in surgical patients… -squares subroutine of our microcomputer program. Such analysis will …

Immune tolerance in hemophilia-principal results from the International Registry

G Mariani, A Ghirardini… - Thrombosis and …, 1994 - thieme-connect.com
… in hemophilia A ranges from 3.6 to 21%, depending in part, on whether the case reports
include all patients with hemophilia … and statistics program for epidemiology on microcomputers. …

Risk-XLR: A microcomputer-based genetic risk program for X-linked recessive traits

ML Rivas, PR Martens - Proceedings of the Annual Symposium on …, 1987 - ncbi.nlm.nih.gov
program can handle large pedigrees containing up to 10 women whose genotype is unknown.
Hemophilia … clinics may especially benefit from these programs. Educators involved in the …

Evaluation of factor VIII pharmacokinetics in hemophilia‐A subjects undergoing surgery and description of a nomogram for dosing calculations

G Longo, A Messori, M Morfini, F Baudo… - American journal of …, 1989 - Wiley Online Library
… A microcomputer program was used for this estimation [7]. Goodness of fit was evaluated
for each curve by computing the weighted sum of squared deviations (SSD) between …

Risk-XLR: AMicrocomputer-based Genetic Risk Program for X-Linked Recessive Traits

ML Rivas, PR Martens - europepmc.org
Hemophilia and Duchenne muscular dystrophy specialty clinics … -XLR, a program written
in Microsoft BASIC, in response to these needs. The Macintosh microcomputer was chosen as …

A calculator program for clinical application of the Bayesian method of predicting plasma drug levels

S Ruffo, A Messori, TH Grasela, G Longo… - Computer Programs in …, 1985 - Elsevier
… with those determined by a Bayesian program (ADVISE) designed for microcomputers. …
In this example, the HP-41 program is used to analyze the data of a hemophilia patient with a …

Strategies for individualized dosing of clotting factor concentrates and desmopressin in hemophilia A and B

T Preijers, LM Schütte, MJHA Kruip… - Therapeutic drug …, 2019 - journals.lww.com
… Most patients with severe hemophilia and nonsevere hemophilia who regularly experience
… of hemophilia (more infusions in patients with hemophilia A than in patients with hemophilia B…

A limited sampling strategy for estimating individual pharmacokinetic parameters of coagulation factor VIII in patients with hemophilia A

M Bolon-Larger, V Chamouard… - Therapeutic drug …, 2007 - journals.lww.com
… in the treatment of patients with hemophilia attributable to … -concentration data in patients
with hemophilia A before surgery. … were obtained from a group of 33 patients according to a two-…

Pharmacokinetics of coagulation factors: clinical relevance for patients with haemophilia

S Björkman, E Berntorp - Clinical pharmacokinetics, 2001 - Springer
… Typical average CL in patients with normal vWF levels is 3 ml/h/kg, with an apparent volume
of distribution at steady state (V ss ) that slightly exceeds the plasma volume of the patient, …

A moderate form of hemophilia B is caused by a novel mutation in the protease domain of factor IXVancouver

VA Geddes, BF Le Bonniec, GV Louie… - Journal of Biological …, 1989 - ASBMB
A genomic phage library was constructed using lymphocyte DNA from a patient with cross-reacting
material-positive, moderately severe hemophilia B. The library was screened by …