… biosynthesis of anticoagulant HS and unique substrate specificities among the isoforms, we
investigated the mechanism of 3-OSTs using a structural biology approach coupled with site-…

… of sulfation determine the binding specificity for ligand proteins. These “fine structures” of
heparan sulfate are mainly produced by the regulated introduction of sulfate groups at the N-, 2-…

… This chapter discusses the structural aspects and structure–activity relationships of
heparin/heparan sulfate (HS). The molecular mechanism behind the anticoagulant/antithrombotic …

… protein binding affinity and specificity remain to be fully defined. Thus, the aim of this review
is to evaluate the current state of understand ing of the structural specificity that underlies HS…

… , and there are multiple 3-O-sulfotransferase isoforms having different substrate specificities.
Given its relative rarity as well as the cloning and characterization of the biosynthetic …

… heparan sulfate lyase [heparitinase (EC 4.2.2.8)] indicated close similarities in their depolymerization
of heparan sulfate… the structural/sequence analysis of heparin and heparan sulfate. …

… First, it should be possible to refine our understanding of the catalytic specificities of the …
libraries will be needed to elucidate substrate specificities in depth. Secondly, we need to …

… 2012 On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding
sites on antithrombin and thrombin are fundamentally different. PLoS ONE 7, e48632. …

… have heterogeneous structures that vary with tissue source. However, due to the sequential
nature of the process, and the substrate specificities of the enzymes involved, the structural …

… specificity of the purified recombinant human heparanase was investigated for the first time
using a series of structurally … tetrasaccharide and designing heparan sulfate-based specific …