… sequencing of heparin and heparan sulfate (Linhardt … heparin or heparan sulfate. These
enzymes are applied to polymeric substrates in an effort to understand their range of specificities…

… and heparan sulfate. The prevailing view is that heparanase recognizes specific sulfation
patterns in heparan sulfate. … is capable of varying its substrate specificities depending on the …

… In the study presented here, we further investigated the substrate specificity of the … sulfate
donor 3‘-phosphoadenosine 5‘-phospho[ 35 S]sulfate. Incubations with O-desulfated heparin, …

… Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally
… Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally …

… ) are an evolutionally conserved family of heparan sulfate (HS)-specific 6-O-endosulfatases. …
, QSulf1 and QSulf2, exhibit the same substrate specificity toward a subset of trisulfated …

… The 6O-sulphate groups on glucosamine units, supposed to … We have studied the substrate
specificities of the re… 5 -phospho[35S]sulphate as sulphate donor. All three enzymes catalyse …

… (b) Chemical structures of oligosaccharides used to probe substrate specificities of mutants.
The 6-O-sulfation site in each substrate is circled. The IdoA2S residue in substrates IV to VII …

… residues determine substrate specificity. By understanding these subtle differences, we may
be able to alter the substrate specificity of these enzymes to create more specific enzymes …

… molecular weight heparin as well as anecdot al evidence of secondary benefits of heparin
unrelated … Biosynthesis of heparin and heparan sulfate. The biosynthesis involves initial chain …

… Heparanase cleaves heparan sulfate (HS), a sulfated … Here, we sought to determine the
specificity of heparanase using … understanding of the substrate specificity of heparanase and …