… Uptake of fatty acids in excess of metabolic requirements will lead to storage as triglycerides,
resulting in steatosis and providing substrate for lipid peroxidation. Fatty acid uptake may …

… If the alterations of hepatic lipid metabolism leading to NAFLD were understood, it might
be possible to prevent or reverse steatosis before progression to steatohepatitis. This goal …

… hepatic fatty acid uptake, fatty acid synthesis, and esterification (‘input’) and hepatic fatty acid
… Moreover, and interestingly, fatty acids regulate overall lipid metabolism by binding nuclear …

… omega-3 fatty acids on hepatic lipid metabolism and on inflammatory pathways affecting
development of NAFLD. Furthermore, we discuss the role of omega-3 fatty acids as a potential …

… Under healthy conditions, the liver regulates lipid metabolism to meet systemic energy … of
fatty acid uptake, fatty acid synthesis and the intracellular partitioning of fatty acids into storage, …

… enter the hepatocytes has not yet been fully elucidated, but it appears that FATP5 plays a
major role in hepatocellular uptake of fatty acids [17]. Furthermore, hepatocytes contain …

… transport proteins and cellular enzymes. We will review available data on different steps of
hepatic lipid metabolism in … is an imbalance in which fatty acid uptake and de novo synthesis …

… of hepatic oxidative and biosynthetic fluxes are relatively well understood. In essence, there
is a high flux through fatty acid β-… Based on the known rates of hepatic fatty acid oxidation, …

… dietary lipid ingestion or alternatively in association with changes in hepatic fatty acid uptake…
An important component of such accommodation likely occurs following fatty acid uptake …

… 2 Role of hepatic fatty acid metabolism in the development of hepatic steatosis. Hepatic lipid
… insulin resistance, (3) impairment of fatty acid oxidation and mitochondrial function, and (4) …