… effects of metformin and rosiglitazone in newly diagnosed type 2 diabetes patients. In this
study, insulin-mediated glucose uptake was enhanced by rosiglitazone but not by metformin. …

… Biguanides and thiazolidinediones (TZDs) are well known to … metformin, the only biguanide
in clinical use, and the TZDs pioglitazone and rosiglitazone, on hepatic glucose metabolism …

… Metformin exerts a stronger suppression of hepatic glucose output, while thiazolidinediones
… in peripheral glucose uptake, enabling metformin-thiazolidinedione combinations to …

… seemed to be more effective in metabolic control and histological improvement in NAFLD
patients with impaired glucose metabolism and metformin therapy alone has not improve …

… not hyperinsulinaemic only the hepatic effect was observed with … hepatic glucose uptake
without affecting peripheral glucose … indicating that troglitazone and metformin can act additively …

… potential for differential regulation of hepatic lipid metabolism by PPAR-γ agonists … glucose
uptake and blood flow increased 56 and 57%, respectively, with RGZ and 24% with metformin…

… The biguanide, metformin, sensitizes the liver to the effect of insulin, suppressing hepatic
glucose output. Thiazolidinediones such as rosiglitazone and pioglitazone enhance insulin-…

… Metformin acts by inhibiting gluconeogenesis in the liver, stimulating peripheral uptake of
glucose … and TZD exerted similar positive effects with regard to changes in glucose metabolism…

… with the biguanide metformin. TZDs act in a different and complementary manner to … where
it can increase glucose uptake. The presence of PPARγ in liver may facilitate some effects of …

… to contribute to the action of the antidiabetic agent metformin [128, 129]. Evidence for direct
… hepatic glucose metabolism in vitro, but the precise contribution of direct effects on the liver …