Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance
FR Jornayvaz, GI Shulman - Cell metabolism, 2012 - cell.com
… , hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked
to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of …
to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of …
Roles of diacylglycerols and ceramides in hepatic insulin resistance
MC Petersen, GI Shulman - Trends in pharmacological sciences, 2017 - cell.com
… links hepatic lipid accumulation with hepatic insulin resistance, … Diacylglycerols (DAGs) and
ceramides have emerged as the … of lipid-induced hepatic insulin resistance. Both lipids were …
ceramides have emerged as the … of lipid-induced hepatic insulin resistance. Both lipids were …
Does diacylglycerol accumulation in fatty liver disease cause hepatic insulin resistance?
BN Finck, AM Hall - BioMed Research International, 2015 - Wiley Online Library
… The link between PKCε activation and hepatic insulin resistance is supported in
correlative fashion by several papers [12, 13, 16, 23, 24] and in more convincing fashion by “knocking …
correlative fashion by several papers [12, 13, 16, 23, 24] and in more convincing fashion by “knocking …
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
FR Jornayvaz, AL Birkenfeld… - Proceedings of the …, 2011 - National Acad Sciences
… , hepatic insulin resistance in … hepatic steatosis and hepatic insulin resistance and support
the hypothesis that DAG-induced PKCε activation plays a major role in nonalcoholic fatty liver …
the hypothesis that DAG-induced PKCε activation plays a major role in nonalcoholic fatty liver …
A membrane-bound diacylglycerol species induces PKCϵ-mediated hepatic insulin resistance
K Lyu, Y Zhang, D Zhang, M Kahn, KW Ter Horst… - Cell metabolism, 2020 - cell.com
… liver insulin resistance. These findings provide important new insights into the pathogenesis
of liver insulin resistance … in plasma insulin concentration activates hepatic insulin signaling …
of liver insulin resistance … in plasma insulin concentration activates hepatic insulin signaling …
Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes
AL Birkenfeld, GI Shulman - Hepatology, 2014 - journals.lww.com
… fatty liver disease (NAFLD), hepatic insulin resistance, and … between NAFLD and hepatic
insulin resistance is controversial… in hepatic diacylglycerol (DAG) content leading to activation of …
insulin resistance is controversial… in hepatic diacylglycerol (DAG) content leading to activation of …
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
… hepatic insulin resistance in obese people with NAFLD, and likely contributes to the inverse
relationship observed between IHTG content and hepatic insulin sensitivity… insulin resistance …
relationship observed between IHTG content and hepatic insulin sensitivity… insulin resistance …
Hepatic diacylglycerol-associated protein kinase Cε translocation links hepatic steatosis to hepatic insulin resistance in humans
KW Ter Horst, PW Gilijamse, RI Versteeg… - Cell reports, 2017 - cell.com
… that link hepatic steatosis to hepatic insulin resistance, we comprehensively analyzed liver
… These results demonstrate the relevance of hepatic diacylglycerol-induced PKCε activation …
… These results demonstrate the relevance of hepatic diacylglycerol-induced PKCε activation …
Muscular diacylglycerol metabolism and insulin resistance
S Timmers, P Schrauwen, J de Vogel - Physiology & behavior, 2008 - Elsevier
… TZDs activate peroxisome proliferator γ (PPARγ) receptors in … the redistribution of fat from
liver and muscle into adipocytes … aberrant activation of PKC and decreased insulin sensitivity, …
liver and muscle into adipocytes … aberrant activation of PKC and decreased insulin sensitivity, …
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
J Szendroedi, T Yoshimura, E Phielix… - Proceedings of the …, 2014 - National Acad Sciences
… diacylglycerol content was temporally associated with protein kinase Cθ activation and
impairment of insulin … diacylglycerol content and protein kinase Cθ activation was observed in …
impairment of insulin … diacylglycerol content and protein kinase Cθ activation was observed in …
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