… , hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked
to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of …

… links hepatic lipid accumulation with hepatic insulin resistance, … Diacylglycerols (DAGs) and
ceramides have emerged as the … of lipid-induced hepatic insulin resistance. Both lipids were …

… The link between PKCε activation and hepatic insulin resistance is supported in
correlative fashion by several papers [12, 13, 16, 23, 24] and in more convincing fashion by “knocking …

… , hepatic insulin resistance in … hepatic steatosis and hepatic insulin resistance and support
the hypothesis that DAG-induced PKCε activation plays a major role in nonalcoholic fatty liver …

… liver insulin resistance. These findings provide important new insights into the pathogenesis
of liver insulin resistance … in plasma insulin concentration activates hepatic insulin signaling …

… fatty liver disease (NAFLD), hepatic insulin resistance, and … between NAFLD and hepatic
insulin resistance is controversial… in hepatic diacylglycerol (DAG) content leading to activation of …

… hepatic insulin resistance in obese people with NAFLD, and likely contributes to the inverse
relationship observed between IHTG content and hepatic insulin sensitivity… insulin resistance …

… that link hepatic steatosis to hepatic insulin resistance, we comprehensively analyzed liver
… These results demonstrate the relevance of hepatic diacylglycerol-induced PKCε activation …

… TZDs activate peroxisome proliferator γ (PPARγ) receptors in … the redistribution of fat from
liver and muscle into adipocytes … aberrant activation of PKC and decreased insulin sensitivity, …

… diacylglycerol content was temporally associated with protein kinase Cθ activation and
impairment of insulin … diacylglycerol content and protein kinase Cθ activation was observed in …