Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice

LG Guidotti, A Morris, H Mendez, R Koch… - Journal of …, 2002 - Am Soc Microbiol
… (IFN-γ) inhibits hepatitis B virus (HBV) replication noncytopathically in the livers of transgenic
mice. … mice replicate HBV in the liver at slightly higher levels than the respective controls, …

Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones

T Pollicino, L Belloni, G Raffa, N Pediconi, G Squadrito… - Gastroenterology, 2006 - Elsevier
… the result of the control of viral replication by the host immune system.33, 34, 35 However,
cellular pathways and viral targets involved in this “control” of viral replication by the immune …

Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells

T Severi, C Ying, JR Vermeesch, D Cassiman… - Molecular and Cellular …, 2006 - Springer
… We used human hepatoma HepAD38 cells, in which HBV production is under the control
of a tetracycline-regulated promotor, to investigate changes induced in the host …

Hepatitis B virus replication induces methylation of both host and viral DNA

P Vivekanandan, HDJ Daniel, R Kannangai… - Journal of …, 2010 - Am Soc Microbiol
Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from
chronic hepatitis B virus (… mechanism, and methylation of viral DNA leads to downregulation …

High-level hepatitis B virus replication in transgenic mice

LG Guidotti, B Matzke, H Schaller, FV Chisari - Journal of virology, 1995 - Am Soc Microbiol
… duck hepatitis B virus, can be grown in tissue culture (34). … woodchuck hepatitis virus and
that of duck hepatitis B virus are … , 22) proteins under the control of HBV or cellular liver-specific …

Selective inhibition of hepatitis B virus replication by RNA interference

C Ying, E De Clercq, J Neyts - Biochemical and Biophysical Research …, 2003 - Elsevier
… Similarly, transfection of lipofectamine alone had no effect on viral replication. Neither
siRNA nor the control compounds caused any cytotoxic or cytostastic effect, as was observed …

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

BE Korba, JL Gerin - Antiviral Research, 1992 - Elsevier
… EC90 values (90% effective concentration: drug concentration which induces a 90% decrease
in the levels of HBV DNA replication intermediates in treated versus untreated control cells

Hepatitis B virus infection

MF Yuen, DS Chen, GM Dusheiko… - Nature reviews Disease …, 2018 - nature.com
… transmission and extrahepatic manifestations of hepatitis B. Another situation in which
treatment would be indicated is for the rapid control of viral replication in patients with severe HBV …

Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway

H Guo, T Zhou, D Jiang, A Cuconati, GH Xiao… - Journal of …, 2007 - Am Soc Microbiol
… Those observations imply that HBV replication might normally be controlled in cells by
the activation of tyrosine kinase-mediated signaling pathways and possibly by the PI3K-Akt …

Natural killer T cell activation inhibits hepatitis B virus replication in vivo

K Kakimi, LG Guidotti, Y Koezuka… - The Journal of …, 2000 - rupress.org
… response, has the potential to control viral replication during natural HBV infection. In addition,
the data suggest that therapeutic activation of NKT cells may represent a new strategy for …