… This review discusses the epigenetic alterations in hepatocellular carcinoma focusing DNA
methylation. Keywords: Hepatocellular carcinoma, DNA methylation, Histone modification, …

… research using the keywords “hepatocellular carcinoma or hepatocarcinoma or primary
liver cancer or HCC or hepatic carcinoma or liver tumor” and “DNA methylation” from PubMed, …

… DNA methylation is an epigenetic regulator of gene expression that … methylation of tumour
suppressor genes is an early event in many tumours, suggesting that altered DNA methylation …

… There is no clear understanding of the epigenetic alterations in hepatocellular carcinoma
(HCC) and of the potential role of DNA methylation markers as prognostic biomarkers. Analysis …

… In this review, we will focus specifically on DNA methylation, another … DNA methylation
could be the alternative factor contributing towards liver carcinogenesis. DNA methylation occurs …

… in DNA methylation frequently occur in hepatocellular cancer (… can be detected in plasma
DNA before HCC diagnosis. To … Hepatocellular carcinoma displays distinct DNA methylation …

… of hepatocellular carcinoma (HCC) and with exposure to environmental agents, we examined
the methylation … Methods: We examined the methylation status of 12 CpG islands (eight for …

… Altered DNA methylation such as tumor suppressor gene hypermethylation or oncogene …
Given that methylation is potentially reversible, detection of such aberrant DNA methylation …

… DNA methylation in general and in cancer in particular.This short review focuses on current
knowledge of DNA methylation … A marked reduction in the overall level of DNA methylation …

… In this study we aimed to identify the contribution of DNA methylation changes as potential
contributors in the earliest steps of human HCC. Inclusion of a reasonably large number of …