[HTML][HTML] PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease

L Valenti, P Dongiovanni, SG Corradini… - Digestive and Liver …, 2013 - Elsevier
… a role of genetic mutations in the … rs738409 genetic variant in the patatin-like phospholipase
domain-containing 3 (PNPLA3, adiponutrin) gene, which has been implicated as a genetic

Genetic Variants of Glutathione S-Transferase as Possible Risk Factors for Hepatocellular Carcinoma: A HuGE Systematic Review and Meta-Analysis

DL White, D Li, Z Nurgalieva… - American journal of …, 2008 - academic.oup.com
… in genes encoding glutathione S-transferases (GSTs), phase II isoenzymes involved in cellular
detoxification, on risk of hepatocellular carcinoma (HCC)… interesting gene-gene and gene-…

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

MA Burza, C Pirazzi, C Maglio, K Sjöholm… - Digestive and Liver …, 2012 - Elsevier
… I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) …
the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from …

Genetics of hepatocellular carcinoma: approaches to explore molecular diversity

S Caruso, DR O'Brien, SP Cleary, LR Roberts… - …, 2021 - Wiley Online Library
… However, future integration of genetic variants with clinical features may improve the … PNPLA3
and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies …

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study

E Trépo, S Caruso, J Yang, S Imbeaud… - The Lancet …, 2022 - thelancet.com
Hepatocellular carcinoma is a frequent consequence of … genetic variants for alcohol-related
hepatocellular carcinoma… related hepatocellular carcinomas were enriched in CTNNB1 gene

[PDF][PDF] Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

F Stickel, P Lutz, S Buch, HD Nischalke, I Silva… - …, 2020 - Wiley Online Library
… This study explores the risk associations between these two genetic variants and the … -related
cirrhosis are at risk for developing hepatocellular carcinoma (HCC); the annual incidence …

A Genetic Variant in Long Non-Coding RNA HULC Contributes to Risk of HBV-Related Hepatocellular Carcinoma in a Chinese Population

Y Liu, S Pan, L Liu, X Zhai, J Liu, J Wen, Y Zhang… - PloS one, 2012 - journals.plos.org
Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the seventh in
… HBV persistent carriers developed HCC, suggesting genetic variation may play roles in the …

Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis

P Nahon, J Bamba-Funck, R Layese, E Trépo… - Journal of …, 2023 - Elsevier
Background & Aims Identifying individuals at higher risk of developing hepatocellular
carcinoma (HCC) is pivotal to improve the performance of surveillance strategies. Herein, we …

Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction

MM Hassan, A Kaseb, CJ Etzel… - Molecular …, 2013 - Wiley Online Library
… 3 (PNPLA3) gene is associated with high … this variation and hepatocellular carcinoma (HCC)
has not been well established. We investigated the impact of PNPLA3 genetic variation (…

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

F Stickel, S Buch, HD Nischalke, KH Weiss… - Official journal of the …, 2018 - journals.lww.com
… Within this population, PNPLA3rs738409 is also an established risk factor for the development
of hepatocellular carcinoma (HCC). The aim of this study was to explore possible risk …