Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: a review

B Hu, JZ Lin, XB Yang, XT Sang - Cell proliferation, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide
… Meanwhile, immune cells are also known as key players in the HCC microenvironment and …

[HTML][HTML] Epigenetic and immune-cell infiltration changes in the tumor microenvironment in hepatocellular carcinoma

ZH Wu, DL Yang, L Wang, J Liu - Frontiers in immunology, 2021 - frontiersin.org
… We then applied the ssGSEA to contrast immune cellcells (DCs), neutrophils, MHC I,
and regulatory T cells (Treg), suggesting that cluster A could play a key role in tumor immunity. …

Hepatocellular carcinoma from an immunologic perspective

TF Greten, AG Duffy, F Korangy - Clinical Cancer Research, 2013 - AACR
immune cell subsets, cytokines, and chemokines have been studied in hepatocellular
carcinoma … results from different immune-based approaches in hepatocellular carcinoma. These …

[HTML][HTML] Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma

Y Peng, C Liu, M Li, W Li, M Zhang, X Jiang… - Cancer cell …, 2021 - Springer
… We estimated the immune cell infiltration in TME via CIBERSORT and immunotherapy …
levels of immune cells in TME and the activity of immune cells and stromal cells, respectively. …

Immune pathogenesis of hepatocellular carcinoma

Y Nakamoto, LG Guidotti, CV Kuhlen… - The Journal of …, 1998 - rupress.org
Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV…
This study demonstrates that chronic immune-mediated liver cell injury triggers the …

Immunotherapies for hepatocellular carcinoma

JKH Liu, AF Irvine, RL Jones, A Samson - Cancer Medicine, 2022 - Wiley Online Library
… The multitude of effects of immune … of hepatocellular carcinoma progression. Targets
include receptor/ligand pairs found on innate immune cells including natural killer (NK) cells (eg …

Comprehensive analyses of the infiltrating immune cell landscape and its clinical significance in hepatocellular carcinoma

Z Zhang, Z Wang, Y Huang - International Journal of General …, 2021 - Taylor & Francis
… between infiltrating immune cells and prognosis, as well as the development of immunotherapy
in hepatocellular carcinoma (HCC). Thus, analyses of the immune cell landscape are …

[HTML][HTML] Immune-based therapies for hepatocellular carcinoma

DJ Pinato, N Guerra, P Fessas, R Murphy, T Mineo… - Oncogene, 2020 - nature.com
… LSECs are endowed with antigen-presenting capacity, being able to activate antigen
specific CD4+ T-cell responses [13]. LSECs modulate immune cell recruitment through specific …

The distribution of immune cells within combined hepatocellular carcinoma and cholangiocarcinoma predicts clinical outcome

BH Zheng, JQ Ma, LY Tian, LQ Dong… - Clinical and …, 2020 - Wiley Online Library
… In our study, the immune cluster based on the density of immune cells indicated that …
distribution of immune cells. The cluster 1 was abundant in CD3 + and CD8 + T cells across all …

[HTML][HTML] Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review

K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
… rate of all cancers worldwide, with hepatocellular carcinoma (HCC) being the most prevalent
… In addition to cancer cells, the TME includes innate and adaptive immune cells, stromal …