The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

B Heinrich, EM Gertz, AA Schäffer, A Craig, B Ruf… - Gut, 2022 - gut.bmj.com
… a typical inflammation-associated cancer. Tissue resident innate lymphoid cells (ILCs) have
… Here, we analysed 371 cases of hepatocellular carcinoma (TGCA tumour type LIHC). Gene …

Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: Current knowledge and future perspectives

N Jacquelot, C Seillet… - International Journal of …, 2021 - mdpi.com
cells’ such as cancer cells. Our understanding of the role of innate lymphoid cells in hepatocellular
carcinoma (HCC… of NK cells and ILC1 in hepatocellular carcinoma and discuss future …

Single‐cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma

Y He, J Luo, G Zhang, Y Jin, N Wang, J Lu, C Li… - Hepatology, 2022 - journals.lww.com
… Of note, the two ILC2 clusters (ILC2a and ILC2b) mainly populated the cells in tumors.
ILC3s represented a minor ILC population with slight elevation in tumors compared with …

NCR− group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development

Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong… - …, 2019 - thelancet.com
Innate lymphoid cells (ILCs) are a newly discovered family of immune cells that have
similar cytokine-secreting profiles as T helper cell subsets. Although ILCs are critical for host …

Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells

B Ruf, B Heinrich, TF Greten - Cellular & molecular immunology, 2021 - nature.com
… -L1) and CTLA-4 to cells of the adaptive immune system has … in the clinical outcome of
hepatocellular carcinoma (HCC). … natural killer cells (NK cells), helper innate lymphoid cells (…

Signaling pathways tuning innate lymphoid cell response to hepatocellular carcinoma

E Bourayou, R Golub - Frontiers in Immunology, 2022 - frontiersin.org
… The contribution of T and B lymphocytes to HCC (12–14) as well as that of myeloid … of
innate lymphoid cells (ILCs) in HCC. ILCs are the innate counterpart of T lymphocytes but lack …

The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

S Curio, GT Belz - Cellular & Molecular Immunology, 2022 - nature.com
hepatocellular carcinoma (HCC), … hepatic immune environment is likely to provide new
insights into much needed treatments for this devastating disease. Group 1 innate lymphoid cells (…

Checkpoint inhibitors modulate plasticity of innate lymphoid cells in peripheral blood of patients with hepatocellular carcinoma

B Heinrich, B Ruf, V Subramanyam, Y Myojin… - Frontiers in …, 2022 - frontiersin.org
Innate lymphoid cells (ILC) are a heterogeneous and plastic population of cells of the
innate immune system. Their role in cancer and specifically in hepatocellular carcinoma is …

Innate immune cells and their interaction with T cells in hepatocellular carcinoma

GQ Hong, D Cai, JP Gong, X Lai - Oncology letters, 2021 - spandidos-publications.com
… ), neutrophils, eosinophils, basophils and innate lymphoid cells and the crosstalk between
the innate and adaptive immune responses in the antitumor process have been discussed. …

Cytokines derived from innate lymphoid cells assist Helicobacter hepaticus to aggravate hepatocellular tumorigenesis in viral transgenic mice

X Han, T Huang, J Han - Gut Pathogens, 2019 - Springer
… It seems a few strains with disrupted intestinal barriers can participate in pathogenesis of
hepatic disease, including hepatocellular carcinoma, by regulating innate lymphoid cells (ILCs) …