Natural killer cell responses in hepatocellular carcinoma: implications for novel immunotherapeutic approaches

S Mantovani, B Oliviero, S Varchetta, D Mele… - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) still represents a significant complication of chronic liver …
Natural killer (NK) cells are an essential component of innate immunity against cancer and …

Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy

P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
… However, accumulating evidences were found that the NK cells were modulated by liver
diseases and liver cancers including hepatocellular carcinoma (HCC) and showed impaired …

Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

C Sun, H Sun, W Xiao, C Zhang, Z Tian - Acta Pharmacologica Sinica, 2015 - nature.com
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the …
Natural killer (NK) cells, which are innate lymphoid cells that have natural cytotoxicity and …

[HTML][HTML] The role of natural killer cells in hepatocellular carcinoma development and treatment: A narrative review

S Juengpanich, L Shi, Y Iranmanesh, J Chen… - Translational …, 2019 - Elsevier
… The most common type of hepatic cancer is hepatocellular carcinoma consisting 70%–90%
of primary hepatic cancer cases with 75% of cases occurring in Asia [2]. HCC is strongly …

Natural killer cell activity in patients with hepatocellular carcinoma: a new prognostic indicator after hepatectomy

A Taketomi, M Shimada, K Shirabe, K Kajiyama… - Cancer, 1998 - Wiley Online Library
… Comparative disease free survival rates of hepatocellular carcinoma patients after hepatectomy
according to natural killer (NK) cell activity. Patients with high NK cell activity of >30% …

Natural killer cell dysfunction in hepatocellular carcinoma: pathogenesis and clinical implications

PS Sung, JW Jang - International journal of molecular sciences, 2018 - mdpi.com
Hepatocellular carcinoma (HCC) is currently the third leading cause of malignancy-related
mortalities worldwide. Natural killer (NK) cells are involved in the critical role of first line …

Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches

SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
Natural killer (NK) cells account for 25–50% of the total number of hepatic lymphocytes, which
implicates that NK cells play an important role in liver immunity. The frequencies of both …

Expanded and activated natural killer cells for immunotherapy of hepatocellular carcinoma

T Kamiya, YH Chang, D Campana - Cancer immunology research, 2016 - AACR
… Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural
killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a …

Impact of natural killer cells on chronic hepatitis C and hepatocellular carcinoma

T Tatsumi, T Takehara - Hepatology Research, 2016 - Wiley Online Library
Natural killer (NK) cells are involved in the pathogenesis of hepatitis C viral (HCV) infection
and hepatocellular carcinoma (HCC). Recent immunological progresses have revealed the …

[PDF][PDF] Frequency and implications of natural killer and natural killer T cells in hepatocellular carcinoma

AM Zahran, AM Ashmawy, A Rayan, A Elkady… - Egypt J …, 2018 - researchgate.net
… A complex role of the immune system has been highlighted in the development and
progression of hepatocellular carcinoma (HCC). Natural Killer cells (NK) and natural killer T cells (…