[HTML][HTML] Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways

L Yu, M Wang, Y Yang, F Xu, X Zhang… - PLoS Computational …, 2021 - journals.plos.org
… This subnetwork was characterized by high average clustering coefficient, high node
degree, and small average shortest path length (Table 2). In other words, the subnetwork was …

[HTML][HTML] Identifying potential drug targets in hepatocellular carcinoma based on network analysis and one-class support vector machine

Z Tong, Y Zhou, J Wang - Scientific reports, 2019 - nature.com
shortest path lengths between DTG nodes and other five types of PDRG nodes, respectively.
More specifically, the average and minimum lengths of the shortest paths … the shortest path

[HTML][HTML] Hepatocellular carcinoma: old friends and new tricks

E Kim, P Viatour - Experimental & molecular medicine, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis, …

Application of the shortest path algorithm for the discovery of breast cancer-related genes

L Chen, Z Hao Xing, T Huang, Y Shu… - Current …, 2016 - ingentaconnect.com
… Identification of hepatocellular carcinoma related genes with k-th shortest paths in a
proteinprotein interaction network. Mol BioSyst 2013; 9: 2720-8. [24] Hornberg JJ, Bruggeman FJ, …

Analysis of protein interaction networks for the detection of candidate hepatitis B and C biomarkers

T Simos, U Georgopoulou… - IEEE Journal of …, 2014 - ieeexplore.ieee.org
… of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). The resolution or …
The average shortest path length of node n is the average length of a shortest path between …

[HTML][HTML] Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma

S Hoehme, F Bertaux, W Weens… - Bulletin of mathematical …, 2018 - Springer
… To ensure that the emerging model is able to simulate both liver regeneration after drug-induced
central liver lobule damage and early states of hepatocellular carcinoma, we …

[HTML][HTML] Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma

X Dong, F Wang, C Liu, J Ling, X Jia, F Shen… - Cell death …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a globally prevailing cancer with a low 5-year survival
rate. Little is known about its intricate gene expression profile. Single-cell RNA sequencing is …

[HTML][HTML] Comprehensive network analysis reveals alternative splicing-related lncRNAs in hepatocellular carcinoma

J Wang, X Wang, A Bhat, Y Chen, K Xu, Y Mo… - Frontiers in …, 2020 - frontiersin.org
… In addition, the method we propose has better accuracy than other previously defined “shortest
path” network-based algorithms, with advantages of overcoming “noise” and “incomplete” …

[HTML][HTML] Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (E ncyclopedia of H epatocellular C arcinoma genes O nline)

CN Hsu, JM Lai, CH Liu, HH Tseng, CY Lin, KT Lin… - BMC …, 2007 - Springer
Hepatocellular carcinoma (HCC) is the most common liver malignancy and is one of the
leading causes of death worldwide. Its incidence has been especially prevalent among Asian …

Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis

S Lee, A Mardinoglu, C Zhang, D Lee… - Nucleic Acids …, 2016 - academic.oup.com
… this object its network characteristics such as shortest path length were analyzed (the third
step … in the integrated network, using a shortest path information generated by igraph. Finally, …