… Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development
of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated …

… YAP/TAZ signaling in this model, we presumed that any tumor- suppressive effects of YAP/TAZ …
shown to effectively suppress the transcriptional activity of YAP/TAZ,(26,27) were used for …

… However, the molecular mechanism of myricetin against hepatocellular carcinoma (HCC) …
that YAP is essential for cancer initiation and progression. However, whether YAP contributes …

… Here, we found that ACADL was frequently downregulated in hepatocellular carcinoma (…
growth suppression through suppressing Hippo/YAP signaling evidenced by decreased YAP …

… We then found that curcumin, a major component of turmeric, suppressed TAZ and YAP
expressions and exerted anticancer effects in HCC cell lines (HepG2 and HLF, which exhibited …

… in the development of hepatocellular carcinoma (HCC) remains … Hippo pathway downstream
effectors YAP and TEAD4 can … Functionally, depletion of CYR61 enhanced TGF-β- or YAP-…

… The data from the current study demonstrated that YAP knockdown was capable of
suppressing tumor growth, increasing the anti-tumor effects of CDDP in the PDTX model. These …

… whether USP10 could influence hepatocellular carcinoma progression by mediating YAP/TAZ.
First, we found that stably silencing USP10 in HepG2 significantly suppressed cell growth, …

… induction in HCC cell lines leads to increased resistance to doxorubicin-induced apoptosis;
whereas, suppression of YAP expression via RNA interference has been noted to reverse …

… Noticeably, our data revealed that the activation of mTOR protein was markedly suppressed
by YAP knockdown and subsequently restored by the ROS scavenger NAC. Furthermore, …