YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression
J Fitamant, F Kottakis, S Benhamouche, HS Tian… - Cell reports, 2015 - cell.com
… Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development
of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated …
of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated …
YAP/TAZ suppress drug penetration into hepatocellular carcinoma through stromal activation
K Cho, SW Ro, HW Lee, H Moon, S Han, HR Kim… - …, 2021 - Wiley Online Library
… YAP/TAZ signaling in this model, we presumed that any tumor- suppressive effects of YAP/TAZ …
shown to effectively suppress the transcriptional activity of YAP/TAZ,(26,27) were used for …
shown to effectively suppress the transcriptional activity of YAP/TAZ,(26,27) were used for …
Myricetin suppresses the propagation of hepatocellular carcinoma via down-regulating expression of YAP
M Li, J Chen, X Yu, S Xu, D Li, Q Zheng, Y Yin - Cells, 2019 - mdpi.com
… However, the molecular mechanism of myricetin against hepatocellular carcinoma (HCC) …
that YAP is essential for cancer initiation and progression. However, whether YAP contributes …
that YAP is essential for cancer initiation and progression. However, whether YAP contributes …
ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinoma
X Zhao, W Qin, Y Jiang, Z Yang, B Yuan, R Dai… - NPJ precision …, 2020 - nature.com
… Here, we found that ACADL was frequently downregulated in hepatocellular carcinoma (…
growth suppression through suppressing Hippo/YAP signaling evidenced by decreased YAP …
growth suppression through suppressing Hippo/YAP signaling evidenced by decreased YAP …
An imbalance in TAZ and YAP expression in hepatocellular carcinoma confers cancer stem cell–like behaviors contributing to disease progression
H Hayashi, T Higashi, N Yokoyama, T Kaida… - Cancer research, 2015 - AACR
… We then found that curcumin, a major component of turmeric, suppressed TAZ and YAP
expressions and exerted anticancer effects in HCC cell lines (HepG2 and HLF, which exhibited …
expressions and exerted anticancer effects in HCC cell lines (HepG2 and HLF, which exhibited …
Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma
C Zhang, W Wei, S Tu, B Liang, C Li, Y Li, W Luo… - Journal of Biological …, 2024 - ASBMB
… in the development of hepatocellular carcinoma (HCC) remains … Hippo pathway downstream
effectors YAP and TEAD4 can … Functionally, depletion of CYR61 enhanced TGF-β- or YAP-…
effectors YAP and TEAD4 can … Functionally, depletion of CYR61 enhanced TGF-β- or YAP-…
Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells
X Wang, B Wu, Z Zhong - Oncology Letters, 2018 - spandidos-publications.com
… The data from the current study demonstrated that YAP knockdown was capable of
suppressing tumor growth, increasing the anti-tumor effects of CDDP in the PDTX model. These …
suppressing tumor growth, increasing the anti-tumor effects of CDDP in the PDTX model. These …
USP10 promotes proliferation of hepatocellular carcinoma by deubiquitinating and stabilizing YAP/TAZ
H Zhu, F Yan, T Yuan, M Qian, T Zhou, X Dai, J Cao… - Cancer research, 2020 - AACR
… whether USP10 could influence hepatocellular carcinoma progression by mediating YAP/TAZ.
First, we found that stably silencing USP10 in HepG2 significantly suppressed cell growth, …
First, we found that stably silencing USP10 in HepG2 significantly suppressed cell growth, …
Emerging role of Hpo signaling and YAP in hepatocellular carcinoma
… induction in HCC cell lines leads to increased resistance to doxorubicin-induced apoptosis;
whereas, suppression of YAP expression via RNA interference has been noted to reverse …
whereas, suppression of YAP expression via RNA interference has been noted to reverse …
YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway
Y Zhou, Y Wang, W Zhou, T Chen, Q Wu… - Cancer cell …, 2019 - Springer
… Noticeably, our data revealed that the activation of mTOR protein was markedly suppressed
by YAP knockdown and subsequently restored by the ROS scavenger NAC. Furthermore, …
by YAP knockdown and subsequently restored by the ROS scavenger NAC. Furthermore, …
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