… confer susceptibility to breast and ovarian cancer and to a … to cancer because familial
breast and/or ovarian cancer tend … and patients with hereditary breast ovarian cancer (HBOC) …

… cancer prone syndromes (2–7). Patients predisposed to breast and ovarian cancers are
known as the hereditary … impact on the management of hereditary breast and ovarian cancers. …

… In women at increased risk for breast and ovarian cancer, the identification of a mutation
in breast cancer gene 1 (BRCA1) and BRCA2 has important implications for screening and …

… risk for either breast or tubo-ovarian cancer with minimal to … risk of breast cancer without
risk of tubo-ovarian cancer, and … have an increased risk for tubo-ovarian cancer, while there is …

Breast cancer (BC) is the most frequent carcinoma in women. The cumulative risk for the
disease is 10% up to the age of 80 years. A familial history of BC and ovarian cancer (OC) is a …

… -associated hereditary breast and ovarian cancer (HBOC) is … breast cancer, ovarian cancer
(including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers …

… managing patients at high risk for hereditary breast cancer. Design: We have studied 98
extended hereditary breast cancer (HBC)/hereditary breast-ovarian cancer (HBOC) families with …

… In case of mutations in the BRCA2 gene, the cumulative risk of breast cancer up to the age
70 years is 84% [2]. The risk of ovarian cancer with pathogenic mutations in BRCA1 is 63% by …

… Hereditary breast and ovarian cancers are caused by an autosomal dominant inheritance
with incomplete penetrance. Population-based studies put its penetrance for breast cancer at …

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …