… By evaluating SSCs within their stem cell niche, we show that DNA repair, cell-cycle
checkpoints, and apoptosis function together to maintain the integrity of the heritable genome. …

… We hypothesize that cell chromatin patterns and transient silencing of … stem or progenitor
cells may leave these genes vulnerable to aberrant DNA hypermethylation and heritable gene …

… from epigenetic genome reprogramming during development, stem cell differentiation/de-…
a) mitotic inheritance of epigenetic traits from cell to cell, (b) meiotic epigenetic inheritance from …

… , the most recurrent genomic change in both human embryonic stem cells (hESCs) and … the
genomic and epigenomic stability of pluripotent human cells and the implications for stem cell …

… heritable genome editing of a coat pigmentation gene in haploid mouse embryonic stem
cells … gene in the genome of haploid androgenetic stem cells and confirmed that also in these …

… genome-wide reference “scorecards” for monitoring the quality and utility of 32 human pluripotent
stem cell … also for novel studies of heritable genetic disorders in their human cell types. …

… a proxy for the heritability of gene expression programs. We … cells revert to assume the role
of stem cells. To address this question, we integrated lineage histories derived from heritable …

… gene expression in stem cells is regulated by epigenetic processes that confer a specific
chromatin configuration on gene … DNA sequence, and that are heritable. The best characterized …

… in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable
… We observed an MPN gene signature that was higher in HSC-enriched cell clusters than in …

… (A) Slow inactivation of both copies of a genetic stability gene (loci A 1 and A 2 ) followed by
rapid mutation of another gene, B, as a result of genetic instability. (B, C) The corresponding …