Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

E Bettiol, M Samanovic, AS Murkin… - PLoS neglected …, 2009 - journals.plos.org
… have screened a chemical library containing 2000 compounds … We found three different
families of compounds that inhibit … We found that two of the compounds inhibit replication of the …

Synthesis of Heteroaromatic Compounds

J Sloop - Molecules, 2023 - mdpi.com
… feature the synthesis of new heteroaromatic compounds but also investigate the potential …
a high-throughput screening of their compound collection. One compound was identified as a …

Environmental hazard screening of heterocyclic polyaromatic hydrocarbons: Physicochemical data and in silico models

G Çelik, S Beil, S Stolte… - Environmental Science & …, 2022 - ACS Publications
… predicting S w and log K ow of heteroaromatic compounds. Nevertheless, we found that log
compounds and that use of a class-specific (ie, developed for homo/heterocyclic compounds

Heteroaromatic rings of the future

WR Pitt, DM Parry, BG Perry… - … of medicinal chemistry, 2009 - ACS Publications
… a similarly sized virtual library of synthetically accessible compounds. They calculated that
… They then went on to provide a means to virtually screen this entire chemical space by rapid …

Sensitive assay for laboratory evolution of hydroxylases toward aromatic and heterocyclic compounds

TS Wong, N Wu, D Roccatano, M Zacharias… - SLAS Discovery, 2005 - Elsevier
… Here we describe a screening platform for a broad range of aromatic and O-heterocyclic
The screening platform was validated in a medium-throughput format for identifying novel …

… libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds

A Nefzi, JM Ostresh, J Yu… - … of organic chemistry, 2004 - ACS Publications
chemistry has deeply impacted the drug discovery process by accelerating the synthesis and
screening of large numbers of compounds … and heterocyclic combinatorial libraries derived …

The current status of heterocyclic combinatorial libraries

A Nefzi, JM Ostresh, RA Houghten - Chemical reviews, 1997 - ACS Publications
compounds. This review traces the evolution and evaluation of combinatorial libraries of
heterocyclic compounds … Following screening of the resin-bound library, active compounds were …

1, 2, 3‐Triazole in heterocyclic compounds, endowed with biological activity, through 1, 3‐dipolar cycloadditions

A Lauria, R Delisi, F Mingoia, A Terenzi… - … of Organic Chemistry, 2014 - Wiley Online Library
… were then treated with benzyl azide in the presence of sulfate/metallic copper to generate
new chemical libraries 55, for high-throughput screening, in a relatively short period of time (…

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

PN Kalaria, SC Karad, DK Raval - European journal of medicinal chemistry, 2018 - Elsevier
… Now a day's nitrogen, oxygen and sulfur containing heterocyclic … Here in we report the utility
of a variety of heterocyclic compounds … a library of febrifugine analogues and screened their …

[PDF][PDF] Synthesis of Potentially Biologically Active Aromatic and Hetero-aromatic Compounds

C Reynolds - 2010 - wiredspace.wits.ac.za
… ) for the synthesis of large diverse compound libraries. A review of selected literature identified
… We thus chose to test our synthesised compound library against the HIV enzyme, reverse …