Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening
E Bettiol, M Samanovic, AS Murkin… - PLoS neglected …, 2009 - journals.plos.org
… have screened a chemical library containing 2000 compounds … We found three different
families of compounds that inhibit … We found that two of the compounds inhibit replication of the …
families of compounds that inhibit … We found that two of the compounds inhibit replication of the …
Synthesis of Heteroaromatic Compounds
J Sloop - Molecules, 2023 - mdpi.com
… feature the synthesis of new heteroaromatic compounds but also investigate the potential …
a high-throughput screening of their compound collection. One compound was identified as a …
a high-throughput screening of their compound collection. One compound was identified as a …
Environmental hazard screening of heterocyclic polyaromatic hydrocarbons: Physicochemical data and in silico models
… predicting S w and log K ow of heteroaromatic compounds. Nevertheless, we found that log
… compounds and that use of a class-specific (ie, developed for homo/heterocyclic compounds…
… compounds and that use of a class-specific (ie, developed for homo/heterocyclic compounds…
Heteroaromatic rings of the future
WR Pitt, DM Parry, BG Perry… - … of medicinal chemistry, 2009 - ACS Publications
… a similarly sized virtual library of synthetically accessible compounds. They calculated that
… They then went on to provide a means to virtually screen this entire chemical space by rapid …
… They then went on to provide a means to virtually screen this entire chemical space by rapid …
Sensitive assay for laboratory evolution of hydroxylases toward aromatic and heterocyclic compounds
… Here we describe a screening platform for a broad range of aromatic and O-heterocyclic …
The screening platform was validated in a medium-throughput format for identifying novel …
The screening platform was validated in a medium-throughput format for identifying novel …
… libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds
A Nefzi, JM Ostresh, J Yu… - … of organic chemistry, 2004 - ACS Publications
… chemistry has deeply impacted the drug discovery process by accelerating the synthesis and
screening of large numbers of compounds … and heterocyclic combinatorial libraries derived …
screening of large numbers of compounds … and heterocyclic combinatorial libraries derived …
The current status of heterocyclic combinatorial libraries
A Nefzi, JM Ostresh, RA Houghten - Chemical reviews, 1997 - ACS Publications
… compounds. This review traces the evolution and evaluation of combinatorial libraries of
heterocyclic compounds … Following screening of the resin-bound library, active compounds were …
heterocyclic compounds … Following screening of the resin-bound library, active compounds were …
1, 2, 3‐Triazole in heterocyclic compounds, endowed with biological activity, through 1, 3‐dipolar cycloadditions
… were then treated with benzyl azide in the presence of sulfate/metallic copper to generate
new chemical libraries 55, for high-throughput screening, in a relatively short period of time (…
new chemical libraries 55, for high-throughput screening, in a relatively short period of time (…
A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
… Now a day's nitrogen, oxygen and sulfur containing heterocyclic … Here in we report the utility
of a variety of heterocyclic compounds … a library of febrifugine analogues and screened their …
of a variety of heterocyclic compounds … a library of febrifugine analogues and screened their …
[PDF][PDF] Synthesis of Potentially Biologically Active Aromatic and Hetero-aromatic Compounds
C Reynolds - 2010 - wiredspace.wits.ac.za
… ) for the synthesis of large diverse compound libraries. A review of selected literature identified
… We thus chose to test our synthesised compound library against the HIV enzyme, reverse …
… We thus chose to test our synthesised compound library against the HIV enzyme, reverse …
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