… that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple
elements in the /in-14 3’UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3’…

… plore how the lin-14 temporal switch is regulated by these other heterochronic genes. On the
… lin-14 in mutants and wild type, we find that lin-28 and lin-4 act antagonistically to regulate …

… Heterochronic genes thus control the relative timing of … in the molecular genetic mechanismsby
which heterochronic genes … in heterochronic gene activity may mediate the heterochronic …

… In a mutant lacking the heterochronic gene lin-28, the vulva completes development one
stage early, and fails to connect to the gonad at the proper time. Whereas the wild-type vulva is …

… order various other known heterochronic genes into the heterochronic pathway. In addition,
… elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin…

… Here, we demonstrate that lin-42 is indeed a negative regulator of heterochronic … lin-42(loss-of-function)
[lin-42(lf)] animals, and genetic analysis places these miRNAs downstream of lin-…

… role for lin-42 in developmental timing We demonstrate that the heterochronic gene lin-42 …
Not only does LIN-42 temporally pattern the hypodermis, but it also times events in the vulva, …

… Citation 4 By acting in opposition to the nuclear receptor and heterochronic gene, daf-12,
LIN-42 … Citation 4 Like other circadian rhythm behaviors, locomoter activity in C. elegans is …

… Here, we discuss the expression and function of heterochronic genes including let-7, miR-125
(the orthologue of lin-4), lin-28 and lin-41 during the metamorphosis of Drosophila and …

… gene lin-41 is the one of the heterochronic genes that regulate the timing of many developmental
events. MicroRNA let-7 negatively regulates the expression of lin-… homologues of lin-41 …