Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
B Wightman, I Ha, G Ruvkun - Cell, 1993 - Elsevier
… that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple
elements in the /in-14 3’UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3’…
elements in the /in-14 3’UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3’…
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
… plore how the lin-14 temporal switch is regulated by these other heterochronic genes. On the
… lin-14 in mutants and wild type, we find that lin-28 and lin-4 act antagonistically to regulate …
… lin-14 in mutants and wild type, we find that lin-28 and lin-4 act antagonistically to regulate …
Temporal pattern formation by heterochronic genes
… Heterochronic genes thus control the relative timing of … in the molecular genetic mechanismsby
which heterochronic genes … in heterochronic gene activity may mediate the heterochronic …
which heterochronic genes … in heterochronic gene activity may mediate the heterochronic …
[HTML][HTML] Heterochronic genes and the nature of developmental time
EG Moss - Current Biology, 2007 - cell.com
… In a mutant lacking the heterochronic gene lin-28, the vulva completes development one
stage early, and fails to connect to the gonad at the proper time. Whereas the wild-type vulva is …
stage early, and fails to connect to the gonad at the proper time. Whereas the wild-type vulva is …
Heterochronic genes in development and evolution
… order various other known heterochronic genes into the heterochronic pathway. In addition,
… elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin…
… elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin…
Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression
KA McCulloch, AE Rougvie - Proceedings of the National …, 2014 - National Acad Sciences
… Here, we demonstrate that lin-42 is indeed a negative regulator of heterochronic … lin-42(loss-of-function)
[lin-42(lf)] animals, and genetic analysis places these miRNAs downstream of lin-…
[lin-42(lf)] animals, and genetic analysis places these miRNAs downstream of lin-…
[HTML][HTML] Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42
JM Tennessen, HF Gardner, ML Volk, AE Rougvie - Developmental biology, 2006 - Elsevier
… role for lin-42 in developmental timing We demonstrate that the heterochronic gene lin-42 …
Not only does LIN-42 temporally pattern the hypodermis, but it also times events in the vulva, …
Not only does LIN-42 temporally pattern the hypodermis, but it also times events in the vulva, …
Period homolog LIN-42 regulates miRNA transcription to impact developmental timing
PM Van Wynsberghe, AE Pasquinelli - Worm, 2014 - Taylor & Francis
… Citation 4 By acting in opposition to the nuclear receptor and heterochronic gene, daf-12,
LIN-42 … Citation 4 Like other circadian rhythm behaviors, locomoter activity in C. elegans is …
LIN-42 … Citation 4 Like other circadian rhythm behaviors, locomoter activity in C. elegans is …
[HTML][HTML] Conservation in the involvement of heterochronic genes and hormones during developmental transitions
F Faunes, J Larraín - Developmental biology, 2016 - Elsevier
… Here, we discuss the expression and function of heterochronic genes including let-7, miR-125
(the orthologue of lin-4), lin-28 and lin-41 during the metamorphosis of Drosophila and …
(the orthologue of lin-4), lin-28 and lin-41 during the metamorphosis of Drosophila and …
Cloning and regulation of the vertebrate homologue of lin‐41 that functions as a heterochronic gene in Caenorhabditis elegans
T Kanamoto, K Terada, H Yoshikawa… - … Dynamics: An Official …, 2006 - Wiley Online Library
… gene lin-41 is the one of the heterochronic genes that regulate the timing of many developmental
events. MicroRNA let-7 negatively regulates the expression of lin-… homologues of lin-41 …
events. MicroRNA let-7 negatively regulates the expression of lin-… homologues of lin-41 …
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