Heterocyclic inhibitors of viroporins in the design of antiviral compounds

VA Shiryaev, YN Klimochkin - Chemistry of heterocyclic compounds, 2020 - Springer
… on known ion channels of viruses that cause socially significant diseases. … of heterocyclic
compounds of the viroporins of influenza virus, hepatitis С virus, human immunodeficiency virus

Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2 (3H)-furanone: Anti-avian influenza virus (H5N1) activity

EM Flefel, RE Abdel-Mageid, WA Tantawy, MA Ali… - Acta …, 2012 - hrcak.srce.hr
… 2(3H)-Furanones are a type of five-membered heterocyclic compounds of synthetic and …
important heterocyclic compounds (1, 2). The chemistry of pyrazole-containing compounds is …

Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review

A Mermer, T Keles, Y Sirin - Bioorganic Chemistry, 2021 - Elsevier
… -heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of
these compounds … of 147 against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells. …

Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H5N8)

EAE El‐Helw, ARI Morsy… - Journal of Heterocyclic …, 2021 - Wiley Online Library
… of quinolin-2(1H)-one-based heterocycles, for example, pyrrolone, … toward highly pathogenic
avian influenza virus (H 5 N 8 ). … of the tested compounds against AIV challenge virus (Table …

Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications

GC dos Santos, LM Martins… - … of Heterocyclic …, 2021 - Wiley Online Library
… Although approved as an anti-influenza drug, favipiravir is only considered for … a
countermeasure for novel or re-emerging influenza viruses. In addition, favipiravir is contraindicated …

Nitrogen-based heterocyclic compounds: a promising class of antiviral agents against chikungunya virus

AC Santana, RC Silva Filho, JC Menezes, D Allonso… - Life, 2020 - mdpi.com
heterocyclic compounds as an important class with CHIKV antiviral activity. We summarize
the present understanding on this class of compounds … The anti-influenza activity of coumarin …

The effect of the structure of derivatives of nitrogen-containing heterocycles on their anti-influenza activity

TL Gridina, AS Fedchuk, SS Basok… - … of Heterocyclic …, 2019 - Springer
… At the first stage, before determining the antiviral activity of the compounds against human
influenza viruses, we measured the level of their toxicity in cell cultures later used to examine …

Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

AS Sokolova, OI Yarovaya, MD Semenova… - …, 2017 - pubs.rsc.org
… In summary, we presented a novel series of borneol derivatives containing different
heterocyclic fragments. All of the compounds were investigated against the influenza virus A/Puerto …

Novel purine conjugates with N-heterocycles: Synthesis and anti-influenza activity

VP Krasnov, VV Zarubaev, DА Gruzdev… - … of Heterocyclic …, 2021 - Springer
… these compounds also observed against the influenza B virus (… compounds on the conservative
target of influenza viruses A … fragments of N-heterocycles and 6-aminohexanoic acid as a …

New route to the synthesis of Benzamide-Based 5-aminopyrazoles and their fused heterocycles showing remarkable antiavian influenza virus activity

AMS Hebishy, HT Salama, GH Elgemeie - ACS omega, 2020 - ACS Publications
… was measured for the synthesized compounds with respect to the H5N1 influenza virus strain
A/… The anti-influenza drug zanamivir was used as a positive control. (53) Antiviral bioassay …