… First, HIF-1 is … HIF-1a deficiency manifest developmental defects that involve all three
components of the circulatory system. Second, HIF-1 mediates changes in gene expression that …

… -Lindau (VHL) protein to HIF-1α that has been hydroxylated at … and changes in gene
expression through HIF-1 activation. … Analysis of hypoxia-inducible factor 1α expression and its …

… the activation of specific transcription factors and expression of appropriate target genes.
The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-…

… gene expression that are mediated by the transcriptional activator hypoxia-inducible factor
(HIF… at the locus encoding the O 2 -regulated HIF-1α or HIF-2α subunit has revealed that these …

… Hypoxia-inducible factor 1α (HIF-1α) that regulates genes … examine the expression of HIF-1α
and VEGF gene expressions and … analyzed HIF-1α and VEGF gene expression levels using …

… HIF-1α and HIF-2α target genes, we demonstrate that HIF-2α does regulate a variety of broadly
expressed hypoxia-inducible genes, … gene expression, we show for the first time that HIF-…

… show the increased expression of HIF1α, a transcription factor that controls genes implied in
… Within the limitations of the study, HIF1α expression was not correlated with the outcome of …

… Akt-induced HIF-1α stabilization and transactivation is not a result of direct phosphorylation
of HIF-1α, we used HIF-1α as a substrate in in vitro kinase assays (Fig. 5C). HIF-1α was a …

… Furthermore, seven cDNAs from genes with unknown function or expressed sequence …
gene expression and HIF-1 seems to play a major role in the regulation of hypoxia-induced genes…

… HIF-1α or HIF-1β is embryonically lethal. The HIF-1α −/− embryos succumb, between 9 and
10 days postcoitum (dpc), to loss of mesenchymal cells and impaired vascular development ( …