… In summary, we found in this study that TOP3 effectively eradicated HIF-1-active cells and
as a consequence its application resulted in short-term suppression of angiogenesis in …

… to oxygen and have no HIF-1 activity and hypoxic HIF-1-active cells exist only in portions of
… as HIF-1-active cells, thus making specific imaging and targeting of HIF-1-active cells feasible …

… The protective effects of HIF1 activation following … (1) and in various cell types like macrophages
(10) and endothelial … in mature cells and tissues, it has also been reported that HIF-1 …

… basis for the selectivity of HIF-1 binding and cell-type-… HIF-1 binding in a second cell type,
U87 glioma cells, and assessed the epigenetic landscape across the genome of these two cell …

… of the complex cell-type- and stimulus-specific mechanisms by which HIF-1 activity is regulated;
… and biological processes that are regulated by HIF-1 within a given cell type and (patho)…

… HIF-1 stimulates glycolysis, it also actively represses mitochondrial function and oxygen
consumption by inducing pyruvate dehydrogenase kinase 1 (… means that HIF-1-dependent block …

… -ODD fusion protein to HIF-1-active cells using optical imaging … obtain specific images of
HIF-1-active cells in the ischemic brain … to hypoxic regions and stabilized in HIF-1-active cells. …

… HIF-2α is not transcriptionally active in embryonic stem (ES) cells, as well as possible inhibition
by a HIF-… -type (WT), Hif-1α − / − , and Hif-2α − / − ES cells, we show that HIF-1α induces a …

… target, we were intrigued and surprised by our finding that PDK1 is sufficient to rescue
hypoxic cells that lack the expression of HIF-1α or HIF-2α. Our further studies support a novel …

… cells overexpressing a constitutively active HIF-1α mutant.Repression of HIF-1α in hypoxic
cells … Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin Cancer Res 2007…