… reactive oxygen species (ROS), which leads to the stabilization of HIF1 and the activation of
HIF-1. Wang et al. (45) demonstrated that strong oxidizing reagents impair the expression of …

… Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. …
Hypoxia-inducible factor 1alpha (HIF1alpha) protein is rapidly degraded by the ubiquitin-pro…

… , exhibit elevated levels of HIF-1, and the appearance of HIF-1 in a tumor is associated with
an increased likelihood of metastasis. The activation of HIF-1 may promote tumor growth by …

… HIF-1 consists of a constitutively expressed subunit HIF-1β and an oxygen-regulated subunit
HIF-1α (or its paralogs HIF-2α and HIF… The stability and activity of the α subunit of HIF are …

… factor HIF-1, which consists of an inducible part (HIF-1α) and a constitutive part (HIF-1β). …
We found that nuclear HIF-1α is expressed mostly in the sublining layer and that HIF-1α ex…

… are upregulated by hypoxia-inducible factor 1 (HIF-1), which is a heterodimer of HIF-1α and
HIF-1β/… Under hypoxic conditions, HIF-1α becomes stabilized and both HIF-1α and ARNT are …

… factor HIF-1 (hypoxia-inducible factor 1) plays an essential role in the maintenance of oxygen
homeostasis in metazoan organisms (1, 2). Within any given cell type, HIF-1 controls the …

… HIF-1α and HIF-2α play nonredundant roles came from mouse models in which Hif-2α deletion
leads to phenotypes distinct from those of Hif-… of the relative roles of HIF-1α and HIF-2α in …

… The protective effects of HIF1 activation following preconditioning were described in several
organ systems such as in the heart (6), brain (3, 4), kidney (5), liver (1) and in various cell …

… activity of hypoxia-inducible factor 1 (HIF-1alpha) via specific effect on the HIF-1alpha C-terminal …
with the host cell induces hypoxia-inducible factor 1 alpha. Virology. 2011;414:83-90.. …