… interaction with two types of high affinity receptors that have been … absence of high affinity
antagonists with known affinities for the … of a new highly selective VIP 1 receptor antagonist. …

… In conclusion, the insulin receptor antagonists S661 and S961 exhibit high affinity and
selectivity for the insulin receptor and can be used to unravel the role of insulin receptor signaling …

… Thus, 8-cyclopentyltheophylline has a 1,000-fold higher affinity and a 30-fold higher … an
antagonist with enhanced affinity and selectivity for At adenosine receptors. Such an antagonist …

… These results demonstrate that high affinity binding and signal … time, that a powerful antagonist
acting on the IL4 receptor … forward identification of high affinity antagonists in both systems …

… In summary, SB-277011-A is a dopamine D 3 receptor antagonist with high affinity and
selectivity for D 3 receptors in human and rat with good bioavailability and CNS penetration. SB-…

… Y 2 antagonist T4-[neuropeptide Y (33–36)] 4 . In addition to its high affinity to the neuropeptide
YY 2 receptor we could also show that BIIE0246 has virtually no affinity for neuropeptide …

… be a specific antagonist with high affinity for the 5-HT4 receptor in guinea-pig isolated
ascending colon and rat isolated oesophagus. It behaved as a surmountable antagonist in both pre…

… In conclusion, RS-127445 is a selective, high affinity 5-HT 2B receptor antagonist
suitable for use in vivo. The therapeutic potential of this molecule is being further evaluated. …

… of specific high-affinity receptor antagonists. Three potent NPY receptor antagonists were …
At least two NPY receptor subtypes have been described based on the relative affinity of …

… We hypothesized that an IL-13 antagonist may have profound … , IL-13E13K, bound with 4-fold
higher affinity to the IL-13 receptor … These results demonstrate that high affinity binding and …