… Tfh cell help versus antigen engagement in PC differentiation, we again challenged transferred
SW HEL .Blimp1 gfp/+ B cells … ) or deplete (anti-CD4) Tfh cell help, and the effect on GC …

… To ascertain how T FH -deficient mice generate high-affinity antibodies to S … high affinity
for S and/or RBD and (ii) S-specific B cells may undergo SHM even in the absence of T FH cells …

… follicular helper T cells. Imperfect correlation between BCR affinity for antigen and cognate
T-cell engagement may account for the increasing affinity heterogeneity that accompanies the …

… between antigen-specific TFH cells and antigen-specific GC B cells are … TFH cells, GC B
cells with high affinity receptors are able to capture more antigen from follicular dendritic cells (…

… In contrast, follicular helper T cell (T FH ) effectors are … of proliferation induced by high and
low affinity antigens we were able … dose/low affinity or low dose/high affinity antigen, our data …

… follicles and mature further into GC Tfh cells, and how Tfh cells … antigen and cognate
interactions are important for Tfh cell … low-affinity antigen did not impact Tfh cell differentiation [23]. …

… undergo minimal somatic hypermutations 10 , germinal centers (GCs) where bona fide Tfh
cells select high affinity B cells that have undergone somatic hypermutations 11 might be the …

… hi T FH cells that remained 'resident' in lymph nodes with the highest … the B cell zones to
regulate antigen-primed B cells. Naive antigen-specific helper T cells with TCR of higher affinity '…

… ; in the LZ, B cells with the highest affinity to an antigen 58 are selected by Tfh cells for
further proliferation and maturation. Affinity maturation of GC B 59 cells depends on the right …

… High-affinity antibodies and long-lived memory B cells are … Activated B cells undergo affinity
maturation and differentiation … cells promote the development of GC B cells of higher affinity …