Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor∗

H Qin, J Shi, R Noberini, EB Pasquale… - Journal of Biological …, 2008 - ASBMB
… Here we report the first crystal structure of … is high in the core β-stranded regions, whereas
large variations exist in the loops, particularly the DE and JK loops, which form the high affinity

The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design

VP Jaakola, AP IJzerman - Current opinion in structural biology, 2010 - Elsevier
G-protein-coupled receptors, GPCRs, are key elements in the vertebrate signal transduction
system, and constitute the majority of drug targets. Solved 10 years ago, the crystal structure

Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: structural basis for specificity and high-affinity binding to the …

DC Williams, JY Lee, M Cai, CA Bewley… - Journal of Biological …, 2005 - ASBMB
… We have solved the crystal structures of MVL free and bound to the pentasaccharide Man
3 GlcNAc 2 at 1.9- and 1.8-Å resolution, respectively. MVL is a homodimer stabilized by an …

High-Resolution Crystal Structures of Human Hemoglobin with Mutations at Tryptophan 37β:  Structural Basis for a High-Affinity T-State,

JS Kavanaugh, JA Weydert, PH Rogers, A Arnone - Biochemistry, 1998 - ACS Publications
structure at the β NH 2 termini, the crystal structure of βV1M is virtually identical with the
corresponding structure … , it is clear that in crystal form 1 the quaternary structure transitions for all …

Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 …

GV Avvakumov, I Grishkovskaya, YA Muller… - Journal of Biological …, 2002 - ASBMB
… We have now obtained a crystal structure of the amino-terminal LG domain of human SHBG
… to define the molecular basis of high affinity interactions between SHBG and estradiol …

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site

J Lu, AJ Stewart, PJ Sadler, TJT Pinheiro… - Biochemical Society …, 2008 - portlandpress.com
… An inspection of published X-ray crystal structures of HSA revealed that the only region
which … Location and modelled structure of the high-affinity zinc-binding site on albumin [10] …

Structural studies of a family of high affinity ligands for GPIIb/IIIa

AC Bach, CJ Eyermann, JD Gross… - Journal of the …, 1994 - ACS Publications
… These strongindicators for a preferred conformation are also consistent with several X-ray
crystal structures of 1 where different crystal forms all give rise to essentially the same peptide …

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors

V Apostolopoulos, M Yu, AL Corper, W Li… - Journal of molecular …, 2002 - Elsevier
crystal structure of the high-affinity non-canonical anchor motif peptide YEA9 in complex with
H-2K b and compared it to the high-affinity … positions, has relatively high affinity for H-2K b in …

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope

DC Lowe, S Gerhardt, A Ward, D Hargreaves… - Journal of molecular …, 2011 - Elsevier
… The X-ray crystal structure for the most potent antibody DISC0280 was solved in complex …
the contributions of the VH and VL CDR3 mutations to increased affinity and potency. …

Crystal structure and ligand affinity of avidin in the complex with 4′-hydroxyazobenzene-2-carboxylic acid

P Strzelczyk, G Bujacz - Journal of Molecular Structure, 2016 - Elsevier
… Avidin is a protein found in egg white that binds numerous organic compounds with high
affinity, especially biotin and its derivatives. Due to its extraordinary affinity for its ligands, avidin …