Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor∗
… Here we report the first crystal structure of … is high in the core β-stranded regions, whereas
large variations exist in the loops, particularly the DE and JK loops, which form the high affinity …
large variations exist in the loops, particularly the DE and JK loops, which form the high affinity …
The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design
VP Jaakola, AP IJzerman - Current opinion in structural biology, 2010 - Elsevier
G-protein-coupled receptors, GPCRs, are key elements in the vertebrate signal transduction
system, and constitute the majority of drug targets. Solved 10 years ago, the crystal structure …
system, and constitute the majority of drug targets. Solved 10 years ago, the crystal structure …
Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: structural basis for specificity and high-affinity binding to the …
DC Williams, JY Lee, M Cai, CA Bewley… - Journal of Biological …, 2005 - ASBMB
… We have solved the crystal structures of MVL free and bound to the pentasaccharide Man
3 GlcNAc 2 at 1.9- and 1.8-Å resolution, respectively. MVL is a homodimer stabilized by an …
3 GlcNAc 2 at 1.9- and 1.8-Å resolution, respectively. MVL is a homodimer stabilized by an …
High-Resolution Crystal Structures of Human Hemoglobin with Mutations at Tryptophan 37β: Structural Basis for a High-Affinity T-State,
JS Kavanaugh, JA Weydert, PH Rogers, A Arnone - Biochemistry, 1998 - ACS Publications
… structure at the β NH 2 termini, the crystal structure of βV1M is virtually identical with the
corresponding structure … , it is clear that in crystal form 1 the quaternary structure transitions for all …
corresponding structure … , it is clear that in crystal form 1 the quaternary structure transitions for all …
Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 …
GV Avvakumov, I Grishkovskaya, YA Muller… - Journal of Biological …, 2002 - ASBMB
… We have now obtained a crystal structure of the amino-terminal LG domain of human SHBG
… to define the molecular basis of high affinity interactions between SHBG and estradiol …
… to define the molecular basis of high affinity interactions between SHBG and estradiol …
Albumin as a zinc carrier: properties of its high-affinity zinc-binding site
J Lu, AJ Stewart, PJ Sadler, TJT Pinheiro… - Biochemical Society …, 2008 - portlandpress.com
… An inspection of published X-ray crystal structures of HSA revealed that the only region
which … Location and modelled structure of the high-affinity zinc-binding site on albumin [10] …
which … Location and modelled structure of the high-affinity zinc-binding site on albumin [10] …
Structural studies of a family of high affinity ligands for GPIIb/IIIa
AC Bach, CJ Eyermann, JD Gross… - Journal of the …, 1994 - ACS Publications
… These strongindicators for a preferred conformation are also consistent with several X-ray
crystal structures of 1 where different crystal forms all give rise to essentially the same peptide …
crystal structures of 1 where different crystal forms all give rise to essentially the same peptide …
Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors
V Apostolopoulos, M Yu, AL Corper, W Li… - Journal of molecular …, 2002 - Elsevier
… crystal structure of the high-affinity non-canonical anchor motif peptide YEA9 in complex with
H-2K b and compared it to the high-affinity … positions, has relatively high affinity for H-2K b in …
H-2K b and compared it to the high-affinity … positions, has relatively high affinity for H-2K b in …
Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope
DC Lowe, S Gerhardt, A Ward, D Hargreaves… - Journal of molecular …, 2011 - Elsevier
… The X-ray crystal structure for the most potent antibody DISC0280 was solved in complex …
the contributions of the VH and VL CDR3 mutations to increased affinity and potency. …
the contributions of the VH and VL CDR3 mutations to increased affinity and potency. …
Crystal structure and ligand affinity of avidin in the complex with 4′-hydroxyazobenzene-2-carboxylic acid
P Strzelczyk, G Bujacz - Journal of Molecular Structure, 2016 - Elsevier
… Avidin is a protein found in egg white that binds numerous organic compounds with high
affinity, especially biotin and its derivatives. Due to its extraordinary affinity for its ligands, avidin …
affinity, especially biotin and its derivatives. Due to its extraordinary affinity for its ligands, avidin …