Structural basis for high-affinity peptide inhibition of human Pin1
… High-affinity inhibitors of Pin1 may provide a … two high-resolution X-ray crystal structures
of human Pin1 bound to non-natural peptide inhibitors. The structures of the bound high-affinity …
of human Pin1 bound to non-natural peptide inhibitors. The structures of the bound high-affinity …
Structural basis for a high affinity inhibitor bound to protein kinase MK2
RC Hillig, U Eberspaecher, F Monteclaro… - Journal of molecular …, 2007 - Elsevier
… basis for high affinity interaction with this binding site, we determined the crystal structure of
… We report two structures, produced from soaking into pre-formed crystals of MK2:ADP and …
… We report two structures, produced from soaking into pre-formed crystals of MK2:ADP and …
Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor
JM McDonnell, AJ Beavil, GA Mackay… - Nature structural …, 1996 - nature.com
… Structural models of the two immunoglobulin-like domains of FceRl o-chain were constructed
using the high-resolution crystal structure of the second domain of CD29 as a modelling …
using the high-resolution crystal structure of the second domain of CD29 as a modelling …
Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design
V Apostolopoulos, M Yu, AL Corper, L Teyton… - Journal of molecular …, 2002 - Elsevier
… Here, we report the crystal structure at 1.6 Å resolution of an immunogenic, low-affinity peptide
… determination of H-2K b /MUC1-8 complex which, although of higher affinity (by 100-fold) …
… determination of H-2K b /MUC1-8 complex which, although of higher affinity (by 100-fold) …
High-Resolution Crystal Structure of Plant Carboxylesterase AeCXE1, from Actinidia eriantha, and Its Complex with a High-Affinity Inhibitor Paraoxon,
NR Ileperuma, SDG Marshall, CJ Squire, HM Baker… - Biochemistry, 2007 - ACS Publications
… The structure of AeCXE1 was determined by X-ray crystallography at 1.4 Å resolution. The
crystal structure revealed that AeCXE1 is a member of the α/β-hydrolase fold superfamily, …
crystal structure revealed that AeCXE1 is a member of the α/β-hydrolase fold superfamily, …
… effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2 '-O-ribonucleic …
M Egli, G Minasov, V Tereshko, PS Pallan… - Biochemistry, 2005 - ACS Publications
… the enhanced RNA affinity and nuclease resistance we determined crystal structures of self-…
structure in the vicinity of the 2‘-O-modification all appear to contribute to the improved RNA …
structure in the vicinity of the 2‘-O-modification all appear to contribute to the improved RNA …
Structural basis for high-affinity HER2 receptor binding by an engineered protein
C Eigenbrot, M Ultsch, A Dubnovitsky… - Proceedings of the …, 2010 - National Acad Sciences
… high-affinity binder of HER2. Here we determined the structure of Zher2 in solution and the
crystal structure … structures reveals how high-affinity binding has evolved during selection and …
crystal structure … structures reveals how high-affinity binding has evolved during selection and …
… inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate …
JY Winum, C Temperini, K El Cheikh… - Journal of Medicinal …, 2006 - ACS Publications
… 20 (for which we reported earlier the X-ray crystal structure in complex with CA II) 9b and its
… Furthermore, we report the X-ray crystal structure of the topiramate sulfamide analogue in …
… Furthermore, we report the X-ray crystal structure of the topiramate sulfamide analogue in …
Crystal structure of metarhodopsin II
HW Choe, YJ Kim, JH Park, T Morizumi, EF Pai… - Nature, 2011 - nature.com
… II, presuming that the crystal’s high concentration of opsin in an … Here we present the 3.0 Å
and 2.85 Å crystal structures, … of the high-affinity GαCT peptide 31 and has a similar affinity. …
and 2.85 Å crystal structures, … of the high-affinity GαCT peptide 31 and has a similar affinity. …
Discoidin I from Dictyostelium discoideum and interactions with oligosaccharides: specificity, affinity, crystal structures, and comparison with discoidin II
SV Mathieu, KS Aragão, A Imberty, A Varrot - Journal of molecular biology, 2010 - Elsevier
… a higher affinity for GalNAc than for galactose (Gal). It displays a 48% sequence identity with
DiscII, whose trimeric structure … We present here the specificity and affinity of DiscI and DiscII …
DiscII, whose trimeric structure … We present here the specificity and affinity of DiscI and DiscII …