Synthesis and StructureAffinity Relationships of Selective High-Affinity 5-HT4 Receptor Antagonists: Application to the Design of New Potential Single Photon …

E Dubost, N Dumas, C Fossey, R Magnelli… - Journal of medicinal …, 2012 - ACS Publications
… based on the crystal structures of compounds 4m, 4v, and 11d assuming that the crystalline
… 2 -adrenergic receptor crystal structure, one of the available GPCR structures that exhibits a …

A new, simple, high-affinity glycosidase inhibitor: analysis of binding through X-ray crystallography, mutagenesis, and kinetic analysis

SJ Williams, V Notenboom, J Wicki… - Journal of the …, 2000 - ACS Publications
… this high affinity is due to its binding in the iminol tautomer proposed earlier, the X-ray crystal
structure of the complex of 1 with Cex was determined (Figure 3). This structure shows the …

Structural origins of high-affinity biotin binding to streptavidin

PC Weber, DH Ohlendorf, JJ Wendoloski, FR Salemme - Science, 1989 - science.org
… The high affinity ofthe noncovalent interaction between biotin and streptavidin forms the …
refined crystal structures ofapo and a streptavidin:biotin complex shows that the high affinity

Structure of human α1-acid glycoprotein and its high-affinity binding site

V Kopecký Jr, R Ettrich, K Hofbauerová… - … and biophysical research …, 2003 - Elsevier
… as progesterone, however, its biological function and 3D structure remain unknown [4]. A
3D structure of AGP based on the crystal structure of the bilin-binding protein, a member of the …

Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX

J Phan, Z Li, A Kasprzak, B Li, S Sebti, W Guida… - Journal of Biological …, 2010 - ASBMB
… Here, we determined the crystal structures of MDM2 and MDMX in complex with the pDI and
… quadruple mutant peptide (pDIQ) that displays high affinity for MDMX and is the most potent …

Rational development of high-affinity T-cell receptor-like antibodies

G Stewart-Jones, A Wadle… - Proceedings of the …, 2009 - National Acad Sciences
… Here we present high-resolution crystal structures of 2 Fab antibodies in complex with the
immunodominant NY-ESO-1 157–165 peptide analogue (SLLMWITQV) presented by HLA-A*…

Computational design of ligand-binding proteins with high affinity and selectivity

CE Tinberg, SD Khare, J Dou, L Doyle, JW Nelson… - Nature, 2013 - nature.com
… bind DIG; the model of the higher affinity binder has the most energetically favourable and …
optimize its binding affinity to a picomolar level, and X-ray co-crystal structures of two variants …

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

R Dolot, CH Lam, M Sierant, Q Zhao… - Nucleic Acids …, 2018 - academic.oup.com
… degeneration (15), was modified post-selection using several different moieties to
achieve high affinity binding to human vascular endothelial growth factor-165 (VEGF 165 ) (16). …

Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy

JR Simard, PA Zunszain, CE Ha… - Proceedings of the …, 2005 - National Acad Sciences
… investigation of the relative affinities of binding sites on … high-affinity binding pockets on the
protein. To correlate these peaks with FA-binding sites identified from the crystal structures of …

Structural and thermodynamic studies on cation− π interactions in lectin− ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine− arene …

P Sörme, P Arnoux, B Kahl-Knutsson… - Journal of the …, 2005 - ACS Publications
crystal structure of the human galectin-3C in complex with inhibitor 3, the first structure of a
… The crystal structure of the galectin-3C−3 complex points to the importance of an arginine−…