… One ofthese FcRs is FcϵRI, a multimeric cell surface receptor that bindsimmunoglobulin E
(IgE) with high affinity. The physiological function ofFcϵRI has remained elusive, but its role in …

… the FcεRI complex 1 . The α-chain binds the Fc portion of IgE Footnote 1 ’ with high affinity,
the β… On the basis of several similarities in structural features and signalling targets, FcεRI has …

… of IgE antibodies with the high affinity IgE receptor, FcεRI, is a … of the receptor, the IgE–Fc
and the IgE–Fc:FcεRI complex have … a novel arrangement for the FcεRI ectodomains that is also …

… bind antibodies of the IgE class with high affinity (K d ≈ 10 -9 –10 -10 M). IgE antibodies are
heterotetramers of two heavy and two light chains (H 2 L 2 ), with the FcεRI-binding domains …

… -binding affinity. How affinity variation in the interaction of FcεRI -bound IgE antibodies with
… to unravel how FcεRI distinguishes differences in the affinity of IgE –antigen interactions and …

… rent cell types and the relationship of these receptors to serum IgE … IgE with high affinity
correlated with serum IgE concentrations in vivo. We hypothesized that the numbers of FcϵRI on …

… of IgE-FcεRI binding by trapping IgE with a soluble form of the FcεRI α chain, (2) inhibition
of the IgE-FcεRI … antibody against the FcεRI α chain, (3) suppression of FcεRI expression by …

… Here we show that ligation of the high-affinity IgE receptor (FcεRI) on human monocytes …
FcεRI reduces its own expression but fails to modulate CD95/Fas expression. In contrast, FcεRI …

… Immunoglobulin E (IgE) and its high-affinity receptor (FcεRI) … The interaction of allergens
with FcεRI-bound IgE antibodies is … It is known that the affinity of the interaction between an IgE …

… (CD23), or FcϵRI were involved in the upregulation of FcϵRI by IgE. Methods: The … IgE
(IgE-Fc), which binds to FcϵRI with a greater than 10-fold lower affinity than IgE or wild-type IgE…