… MHC-… MHC–II–peptide binding affinity prediction methods, NetMHCII and NetMHCIIpan.
These were constructed using an extended data set of quantitative MHC–peptide binding affinity …

… In order to define the high-affinity, zinc-dependent site for SAGs on MHC class II, we have
determined the crystal structure, to 3.2 Å resolution, of SPE-C in complex with HLA-DR2a (DRA…

… the affinity of HA 189–197 was increased. Both of the HA peptides had a higher affinity for K
… ) viral peptide has much higher affinity for a particular MHC class I molecule than others and …

… to correlate significantly with high affinity and even more significantly with high stability (p
= 0.017 and p = 0.0004, respectively, unpaired two-tailed Students t-test), (Fig. 2C and D). …

… -binding groove of MHC class II proteins, termed class II-associated invariant chain peptide
(CLIP). This placeholder peptide is then normally exchanged against higher affinity peptides, …

… TAP, and consequently, most class I molecules are transported to the cell surface without a
peptide of sufficiently high affinity to stabilize class I structure at 37C (31). To express peptide-…

… high affinity for binding to the MHC class I molecule of interest on B-LCL cells (cell lines
used: 1341-8346, BSM, E481324, EA, FH8, LKT3, WT100BIS), which were previously stripped …

… and high affinity. This … both class I and class II MHC molecules. Unfortunately, as yet these
data have not allowed us to predict which peptides will bind with high affinity to a specific MHC …

… , due to the contribution of the CD8 co-receptor to class I MHC binding, regardless of bound
peptide. At higher affinity ranges, peptides that are structurally similar to the cognate peptide (…

… of MHC alleles with high affinity. A large number of experiments are typically necessary to
identify mutations that define high-affinity … (1,2) These peptides are presented by MHC class I …