THE HIGH-AFFINITY IgE RECEPTOR (FcϵRI): From Physiology to Pathology

JP Kinet - Annual review of immunology, 1999 - annualreviews.org
high affinity receptor for immunoglobulin E (designated FcϵRI) isthe member of the antigen
(Ag) receptor … other Ag receptors are engaged, newinformation on human receptor structures …

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

M Grell, H Wajant, G Zimmermann… - Proceedings of the …, 1998 - National Acad Sciences
… the affinity of TNF-R1 for TNF is about 20 times higher when compared with equilibrium
binding studies performed at 0C (see above). To further corroborate the high affinity of TNF for …

Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system

ES Vizi - Pharmacological Reviews, 2000 - ASPET
… This review will focus on the role of nonsynaptic receptors and … mediated via receptors
and transports of high affinity not … the first time that the receptors and transporters expressed …

Functional characteristics of the high affinity IgG receptor, FcγRI

CE van der Poel, RM Spaapen… - The Journal of …, 2011 - journals.aai.org
… because of its high affinity, FcγRI is “prearmed” with IgG and functions as a type of scavenger
receptor, analogous to the high-affinity receptor for IgE, FcεRI, or as a sampling receptor of …

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

MR Walter, WT Windsor, TL Nagabhushan, DJ Lundell… - Nature, 1995 - nature.com
… hormone with class-l growth hormone and prolactin receptors"". … high-affinity receptor.
Common to the ligand binding surfaces of the class-2 IFN-y and class-l growth hormone receptors

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

K Teshigawara, HM Wang, K Kato… - The Journal of …, 1987 - rupress.org
… a majority of the low-affinity binding sites, and a low IL-2 concentration that would saturate
only a few low-affinity binding sites but all of the highaffinity receptors. The results, shown in …

The binding site on human immunoglobulin E for its high affinity receptor

L Presta, R Shields, L O'Connell, S Lahr, J Porter… - Journal of Biological …, 1994 - ASBMB
… sponses by binding to specific high affinity receptors, FcdtI, on … ’ E antibodies bind to specific
high affinity receptors, FceRI, on … IgE also binds to low affinity receptors (FceRII, CD23) on B-…

Temperature-sensitive differential affinity of TRAIL for its receptors: DR5 is the highest affinity receptor

A Truneh, S Sharma, C Silverman, S Khandekar… - Journal of Biological …, 2000 - ASBMB
… or both of the death domain containing receptors DR4 and/or DR5, resistance to … receptors.
Previously, TRAIL has been described to bind to all its receptors with equivalent high affinities

The c-erb-A protein is a high-affinity receptor for thyroid hormone

J Sap, A Muñoz, K Damm, Y Goldberg, J Ghysdael… - Nature, 1986 - nature.com
… The receptors for thyroid hormone bind with lower affinity analogues"*" of T, such as
thyroxine (T) and reverse T (rT). We therefore tested if higher concentrations of these analogues …

Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcεRIα

SC Garman, BA Wurzburg, SS Tarchevskaya, JP Kinet… - Nature, 2000 - nature.com
… of IgE antibody to its high-affinity receptor, FcεRI. Crosslinking of FcεRI … The crystal structure
reveals that one receptor binds one … The interaction of one receptor with the IgE-Fc blocks the …